Diagnosis of MGRS in Patients With Paraproteinemias: Clinical, Anatomopathological and Pathophysiological Study
- Conditions
- Monoclonal Gammopathy of Renal Significance
- Registration Number
- NCT03629561
- Lead Sponsor
- Academia Nacional de Medicina
- Brief Summary
This is the first prospective study which evaluate patients with small B-cell clones to diagnose monoclonal gammopathy of renal significance (MGRS) and characterize it clinically, anatomopathologically and pathophysiologically taking int account a geriatric approach.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 15
Inclusion Criteria
- Paraproteinemias
Exclusion Criteria
- Multiple Myeloma
- Waldenstrom Macroglobulinemia
- Chronic Lymphocytic Leukemia
- Malignant Lymphoma
- Monoclonal gammopathy of unknown significance (MGUS) secondary to Infections
- MGUS secondary to Autoimmune Diseases
- Uncompleted hematological evaluation
- Renal tumor except for cysts Bosniak type I/II
- Other malignant neoplasia
- Unresolved obstructive uropathy
- Patients with only one kidney except for renal transplant
- Co-morbidities which would limit the ability to receive aggressive therapeutic intervention
- Fragile old people
- Pregnancy
- Prison
- Impatient in psychiatric institutions.
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Renal histopathology compatible with MGRS through study completion, an average of 1 year
- Secondary Outcome Measures
Name Time Method Renal physiopathological changes through study completion, an average of 1 year
Trial Locations
- Locations (1)
Academia Nacional de Medicina
🇦🇷Buenos Aires, Argentina