NCT03461107Unknown不适用
Evaluation of Beta-adrenergic Receptor Gene Polymorphisms in the Long-term Effects of Beta-blockade in Patients With Chronic Heart Failure
适应症
试验速览
- 阶段
- 不适用
- 入组人数
- 2,500
- 试验地点
- 1
- 主要终点
- Cardiovascular death
研究概览
简要总结
The purpose of this study is to evaluate the beta-adrenergic receptor gene polymorphisms in the long-term effects of beta-blockade in patients with chronic heart failure.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •18 years of age or older;
- •Patients are required to have chronic heart failure (NYHA II-IV) with a left ventricular ejection fraction lower than 40%;
- •Patients are voluntary and signed informed consent.
排除标准
- •Pregnant women or plan to;
- •Participate in any drug clinical trials within 3 months;
- •Serious neurological disease (Alzheimer's disease, Parkinson syndrome, progressive lower limbs or deaf patients);
- •Previous history of cancer or tumor, or pathological examination confirmed precancerous lesions;
- •Patients refused to comply with the requirements of this study to complete the research work;
- •According to the researchers, patients can not complete the study or not to comply with the requirements of this study (because of the reasons for the management or other reasons).
结局指标
主要结局
Cardiovascular death
时间窗: up to 24 months
Heart transplantation
时间窗: up to 24 months
次要结局
- Readmission because of cardiovascular diseases(up to 24 months)
- All cause death(up to 24 months)
- Heart failure recuring(up to 24 months)
研究者
研究点 (1)
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