Critical Care Ultrasound Oriented Shock Treatment in ICU

Not Applicable

Completed

• Conditions: Shock
• Interventions: Other: Critical care ultrasound

• Registration Number: NCT03093987
• Lead Sponsor: West China Hospital

Brief Summary

Objective

To investigate whether critical care ultrasound oriented shock management in shock patients in intensive care unit(ICU) can improve outcome.

Methods

Randomized controlled research. Patients were randomly allocated to two groups. In the critical care ultrasound oriented shock management group (CUSS group), treatment was oriented by the findings of critical care ultrasound in each shock phase, while in the control group the decisions about the monitoring and management were made by the clinical team. The goal of treatments in both groups were decreasing lactate by 20% or more per 2 hours for the Optimization phase in shock management, and no increase lactate level when removing the fluid in de-escalation phase. The primary outcome measure were hospital mortality and 28-day mortality, the secondary outcome measure were the length of ventilation and the length of ICU stay.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2017-03-06
• Study First Submitted QC: 2017-03-22
• Study First Posted: 2017-03-28
• Study Start: 2017-04-05
• Status Verified: 2017-10
• Primary Completion: 2017-10-28
• Study Completion: 2017-10-28
• Last Update Submitted: 2017-10-30
• Last Update Posted: 2017-11-01

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

• SBP <90 mm Hg or MAP <65 mm Hg or SBP decrease >40mmHg or need vasoactive drugs；
• Skin that is cold and clammy，capillary refill time >4.5s，urine output of<0.5ml/Kg.hr and lactate >2mmol/L；
• SHOCK presented within 6 hr.

Exclusion Criteria

• <18 years old；
• Pregnancy；
• Patient or family member refuse to be enrolled.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
critical care ultrasound	Critical care ultrasound	Circulation management will be adjusted according to the results of critical ultrasound combined with clearance of lactic acid in patients with shock.

Primary Outcome Measures

Name	Time	Method
28-day mortality	through study completion,an average of 28 days	28-day mortality

Secondary Outcome Measures

Name	Time	Method
the incidence of AKI	through study completion,an average of 28 days	the incidence of AKI
the total length of hospital stay	through study completion,an average of 28 days	the total length of hospital stay
the length of ICU stay	through study completion,an average of 28 days	the length of ICU stay

Trial Locations

Locations (1)

West China Hospital of Sichuan University; 🇨🇳 Chengdu, Sichuan, China