Changes in Ischemia and Angina Over One Year Among ISCHEMIA Trial Screen Failures
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 212
- 试验地点
- 1
- 主要终点
- Seattle Angina Questionnaire (SAQ) score
研究概览
简要总结
Serial assessment of angina status and ischemia on stress echo over one year among patients with moderate ischemia on stress imaging and non-obstructive CAD on coronary CT angiography.
详细描述
Some people with chest pain are found to have open arteries on angiograms instead of blocked arteries and many, but not all, of these people have abnormal stress tests or other tests showing there is not enough blood flow to the heart. Prior research has not made clear whether chest pain in such patients is due to heart disease or something else, in part because no one has found out whether chest pain and stress test results change in the same direction over time. This study will use two measurements of chest pain and two stress tests, one year apart, to find out if chest pain and abnormal stress tests are both caused by the same problem: not enough blood flow to the heart.The association between angina, ischemia and atherosclerosis severity at baseline will be examined, as will medication effects.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 100 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Enrolled but not randomized in ISCHEMIA trial
- •Stress echocardiography used for enrollment*
- •No obstructive CAD on study coronary CT angiography (defined as no ≥50% stenosis in a major epicardial vessel)
- •Ischemic symptoms (chest pain or other potential ischemic equivalent).
- •Participant is willing to give written informed consent
- •Age ≥ 21 years
排除标准
- •Inability to comply with protocol
- •Prior PCI or CABG
结局指标
主要结局
Seattle Angina Questionnaire (SAQ) score
时间窗: baseline-one year comparison
次要结局
- Ischemia severity(baseline-one year comparison)
- Coronary atherosclerosis severity (comparison with SAQ score and with ischemia severity)(baseline)
- Ischemia severity (comparison with SAQ score and with ischemia severity)(baseline)
- Medical therapy used for angina (comparison with SAQ score and ischemia severity)(one year)
- Major adverse cardiac events(one year)