NCT01882569CompletedNot Applicable
Detection of Immune Changes as a Result of Surgical Trauma in Human Back Surgery Subjects: Optimization of CyTOF Analysis
Martin Angst1 site in 1 country5 target enrollmentStarted: May 2012Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 5
- Locations
- 1
- Primary Endpoint
- Numerical (cell frequencies) and functional (phosphorylation of signaling proteins and transcription factors) changes of all circulating immune cells
Study Overview
Brief Summary
Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study is to use a single cell flow cytometry approach to characterize the cellular and molecular mechanisms involved in the inflammatory response to surgical trauma.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 90 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Ages 18 - 90
- •Men and women
- •Undergo back surgery
Exclusion Criteria
- •Any systemic disease that might compromise the immune system (e.g. lupus)
- •Current diagnosis of cancer
- •Any condition that, in the opinion of the investigator, might compromise the integrity of the study or safety of the participant.
- •Unwilling to sign informed consent
Outcomes
Primary Outcomes
Numerical (cell frequencies) and functional (phosphorylation of signaling proteins and transcription factors) changes of all circulating immune cells
Time Frame: Immediately before to surgery, 1 hour after surgery, 24 hours after surgery, and day of hospital discharge
This is an exploratory study.
Secondary Outcomes
No secondary outcomes reported
Investigators
Martin Angst
Professor of Anesthesia
Stanford University
Study Sites (1)
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