Detection of Immune Changes as a Result of Surgical Trauma in Human Back Surgery Subjects: Optimization of CyTOF Analysis

Martin Angst1 site in 1 country5 target enrollmentMay 2012

ConditionsSurgical Trauma

Overview

Phase: Not Applicable
Intervention: Not specified
Conditions: Surgical Trauma
Sponsor: Martin Angst
Enrollment: 5
Locations: 1
Primary Endpoint: Numerical (cell frequencies) and functional (phosphorylation of signaling proteins and transcription factors) changes of all circulating immune cells
Status: Completed
Last Updated: 10 years ago

Overview Investigators Eligibility Criteria Outcomes Sites Similar Trials

Overview

Brief Summary

Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study is to use a single cell flow cytometry approach to characterize the cellular and molecular mechanisms involved in the inflammatory response to surgical trauma.

Registry

clinicaltrials.gov

Start Date

May 2012

End Date

September 2014

Last Updated

10 years ago

Study Type

Observational

Sex

All

Investigators

Sponsor

Martin Angst

Responsible Party

Sponsor Investigator

Principal Investigator

Martin Angst

Professor of Anesthesia

Stanford University

Eligibility Criteria

Inclusion Criteria

•Ages 18 - 90
•Men and women
•Undergo back surgery

Exclusion Criteria

•Any systemic disease that might compromise the immune system (e.g. lupus)
•Current diagnosis of cancer
•Any condition that, in the opinion of the investigator, might compromise the integrity of the study or safety of the participant.
•Unwilling to sign informed consent