Detection of Immune Changes as a Result of Surgical Trauma in Human Subject
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Surgical Trauma
- Sponsor
- Martin Angst
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- Mass cytometry of immune signaling events
- Status
- Completed
- Last Updated
- 12 years ago
Overview
Brief Summary
Surgical trauma triggers a massive inflammatory response. Over time, both the innate and adaptive branches of the immune system are affected by surgical trauma. The purpose of this study to characterize the cellular and molecular mechanisms immune response to surgical trauma. Additionally, detailed information about patients' recovery profile will be recorded over a period of 6 weeks, with the eventual goal of linking immune responses to recovery profiles.
Investigators
Martin Angst
Professor of Anesthesia
Stanford University
Eligibility Criteria
Inclusion Criteria
- •Planning to undergo hip surgery
- •Fluent in English
- •Willing and able to sign informed consent and HIPAA authorization
Exclusion Criteria
- •Any systemic disease that might compromise the immune system
- •Diagnosis of cancer within the last 5 years
- •Psychiatric, immunological, and neurological conditions that would interfere with the collection and interpretation of study data
- •Pregnancy
- •Any other conditions that, in the opinion of the investigators, may compromise a participant's safety or the integrity of the study
Outcomes
Primary Outcomes
Mass cytometry of immune signaling events
Time Frame: Blood samples for mass cytometry will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op.
The primary molecular outcome is the fold change in phosphorylation of signaling proteins.
Secondary Outcomes
- Surgical Recovery Scale (SRS)(Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks.)
- Plasma cytokines(Blood samples will be drawn at baseline, 1 hour post-op, 24 hours post-op, 3 days post-op, and 6 weeks post-op.)
- Western Ontario and McMaster Universities Arthritis Index (WOMAC)(Data will be collected at baseline, daily through the hospitalization, and every 3 days for 6 weeks.)