Surgical trauma and postoperative immune suppression in breast-conserving surgery versus mastectomy: a pilot study

Recruiting

• Conditions: 10006295; mamma surgery; Breast surgery; 10006291

• Registration Number: NL-OMON48770
• Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 40

Inclusion Criteria

- Female
- Age * 18 years
- Undergoing breast conserving surgery or mastectomy
- Obtained informed consent

Exclusion Criteria

- <18 years old
- No informed consent

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>o Plasma concentration of DAMPs (nDNA, mtDNA, HMGB-1 and HSP70) and cytokines<br /><br>(TNF*, IL6 and IL10)<br /><br>o Ex vivo leucocyte responsiveness: IL-6 and IL-10 production upon LPS<br /><br>stimulation<br /><br>o HLA-DR mRNA expression as a measure of immune suppression<br /><br>o Serum soluble PD-L1</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>