Carpal Tunnel Syndrome and Amyloidosis

Not Applicable

• Conditions: Amyloidosis; Carpal Tunnel Syndrome
• Interventions: Procedure: Carpal tunnel syndrome surgery

• Registration Number: NCT04245098
• Lead Sponsor: Corporacion Parc Tauli

Brief Summary

Carpal tunnel syndrome has been suggested to be an early sign of amyloidosi. The investigators will evaluate tissue samples obtained from patients undergoing carpal tunnel release surgery for amyloid.

Detailed Description

Carpal tunnel syndrome (CTS) can be caused by the deposition and accumulation of misfolded proteins called amyloid and is often an early manifestation of systemic amyloidosis.

Patients with cardiac amyloidosis often have carpal tunnel syndrome that precedes cardiac manifestations by several years, and many patients will have undergone surgery for idiopathic carpal tunnel syndrome since the protein also deposits in the transversal carpal ligament of the hand.

The investigators sought to identify the prevalence and type of amyloid deposits in patients undergoing carpal tunnel surgery and evaluate for cardiac involvement

Study Timeline

• Status Verified: 2020-01
• Study Start: 2020-01-08
• Study First Submitted: 2020-01-22
• Study First Submitted QC: 2020-01-27
• Last Update Submitted: 2020-01-27
• Study First Posted: 2020-01-28
• Last Update Posted: 2020-01-28
• Primary Completion: 2022-01-08
• Study Completion: 2023-01-08

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Patients undergoing carpal tunnel syndrome surgery

Exclusion Criteria

• None

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Amyloid	Carpal tunnel syndrome surgery	Biopsy

Primary Outcome Measures

Name	Time	Method
Number of participants with amyloid deposits in patients undergoing carpal tunnel surgery	2 years	Prevalence of amyloid deposits in biopsy in patients undergoing carpal tunnel syndrome surgery

Secondary Outcome Measures

Name	Time	Method
Number of participants with cardiac involvement in echocardiogram	2 years	Cardiac involment in echocardiography

Trial Locations

Locations (1)

Maria Del Carmen Navarro-Saez; 🇪🇸 Sabadell, Barcelona, Spain