The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
- Conditions
- Hip Fracture
- Registration Number
- NCT00162617
- Lead Sponsor
- Hvidovre University Hospital
- Brief Summary
To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.
- Detailed Description
The effect of liberal vs restrictive transfusion regimens after hip fracture surgery is unresolved. Liberal transfusion regimens (transfusion trigger hgb. 6.25 mmol/l) leads to an increased use of blood products but may impact positively on rehabilitation outcome, a restrictive transfusion trigger (hbg. 5.0 mmol/l) saves blood products but may also impair postoperative rehabilitation and outcome. the study randomizes 120 elderly patients with hip fractures to either a restrictive or a liberal perioperative transfusion therapy and measures postoperative rehabilitation outcomes within a well defined multimodal rehabilitation regimen.
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 120
- Primary hip fracture
- capable of informed consent
- independently dwelling
- able to ambulate independent of human assistance
- no active heart condition defined as no AMI within 3 months, no unstable angina or present incompensation/pulmonary oedema
- no regular transfusion demand or terminal disease.
- Multiple fractures
- postop. immobilization due to to surgical reasons
- patient refusal to participate in relevant rehabilitation
- reoperation within 4. postoperative day.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Postoperative Functional mobility Restricting factors for functional mobility
- Secondary Outcome Measures
Name Time Method Length of stay Complications Dizziness Exhaustion Haematoma (leg swelling)
Trial Locations
- Locations (1)
Hvidovre University Hospital
🇩🇰Hvidovre, Denmark