The Effect of Liberal vs. Restrictive Transfusion Strategies on Rehabilitation After Hip Fracture Surgery
试验速览
- 阶段
- 4 期
- 入组人数
- 120
- 试验地点
- 2
- 主要终点
- Postoperative Functional mobility
研究概览
简要总结
To examine the effect of two different transfusion regimens on rehabilitation after hip fracture surgery.
详细描述
The effect of liberal vs restrictive transfusion regimens after hip fracture surgery is unresolved. Liberal transfusion regimens (transfusion trigger hgb. 6.25 mmol/l) leads to an increased use of blood products but may impact positively on rehabilitation outcome, a restrictive transfusion trigger (hbg. 5.0 mmol/l) saves blood products but may also impair postoperative rehabilitation and outcome. the study randomizes 120 elderly patients with hip fractures to either a restrictive or a liberal perioperative transfusion therapy and measures postoperative rehabilitation outcomes within a well defined multimodal rehabilitation regimen.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Primary hip fracture
- •capable of informed consent
- •independently dwelling
- •able to ambulate independent of human assistance
- •no active heart condition defined as no AMI within 3 months, no unstable angina or present incompensation/pulmonary oedema
- •no regular transfusion demand or terminal disease.
排除标准
- •Multiple fractures
- •postop. immobilization due to to surgical reasons
- •patient refusal to participate in relevant rehabilitation
- •reoperation within
- •postoperative day.
结局指标
主要结局
Postoperative Functional mobility
Restricting factors for functional mobility
次要结局
- Dizziness
- Exhaustion
- Haematoma (leg swelling)
- Length of stay
- Complications