The Effects of an Active Older Adult Program at the Dan Abraham Healthy Living Center on Health and Well-being
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Older Adult
- Sponsor
- Mayo Clinic
- Enrollment
- 33
- Locations
- 1
- Primary Endpoint
- Change in repeated chair rise time
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
The purpose of this study is to determine whether a structured 12-week program designed for older adults will improve physical function and, in parallel, circulating biomarkers of aging
Investigators
Nathan K. LeBrasseur
Principal Investigator
Mayo Clinic
Eligibility Criteria
Inclusion Criteria
- •Men and women age 55 years or older.
- •Membership at the DAHLC.
- •New to AOA (Active Older Adult) Program and commitment to full participation in the twelve-week program.
- •Must be able to get down and off the floor with little assistance.
Exclusion Criteria
- •Inability to provide informed consent.
- •Previous participation in the AOA Program at the DAHLC.
Outcomes
Primary Outcomes
Change in repeated chair rise time
Time Frame: Baseline to end of study, approximately 14 weeks
Chair stand test where participants will perform a chair rise movement for five repetitions. The series of 5 repetitions will be timed and measured in seconds.
Change in plasma protein levels reflective of biological age
Time Frame: Baseline, week 12
Blood samples will be obtained at baseline and at 12 weeks. The concentration of target proteins (pg/mL) in the plasma will be measured and compared between baseline and week 12.
Change in expression of senescence-related genes in blood cells
Time Frame: Baseline, week 12
Blood samples will be obtained at baseline and at 12 weeks. The expression of senescence-related genes (arbitrary units) will be measured in immune cells isolated from whole blood and compared between baseline and week 12.
Secondary Outcomes
- Change in Self-reported Physical Function(Baseline, week 12)
- Change in Performance-based Physical Function(Baseline, week 12)
- Change in Mental Function(Baseline, week 12)
- Change in self-assessment of well-being(Baseline, week 12)