Exercise Training Effects in Patients With Heart Failure

Not Applicable

• Conditions: Chronic Heart Failure
• Interventions: Other: Exercise training

• Registration Number: NCT01071629
• Lead Sponsor: University of Athens

Brief Summary

Chronic heart failure (CHF) is a common syndrome characterized by several central hemodynamic and peripheral vascular and muscle abnormalities including autonomic imbalance, neuro-hormonal over-activation and decreased oxidative status.

In patients suffering from CHF, exercise confers several beneficial effects on the cardiovascular and peripheral systems, mainly by continuous aerobic training. However, interval aerobic training has also been validated as an alternate form of training that increases the exercise capacity of patients who are in CHF.

Recent studies have suggested that resistance training alone or as a complementary program besides the traditionally aerobic continuous training might exert favorable effects. However, little it is known about the combined effects of interval and strength training in CHF patients.

Aim of this prospective randomized controlled study was to investigate the effects of combined interval and strength training comparing to interval training alone in CHF patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-11
• Study First Submitted: 2010-02-18
• Study First Submitted QC: 2010-02-18
• Study First Posted: 2010-02-19
• Primary Completion: 2010-04
• Status Verified: 2015-03
• Last Update Submitted: 2015-03-12
• Last Update Posted: 2015-03-13
• Study Completion: 2015-09

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• Stable systolic heart failure
• NYHA functional class ≤ III
• Optimal medical treatment

Exclusion Criteria

• Contraindications for a maximal cardiopulmonary exercise testing (CPET) according to the American Thoracic Society/American College of Chest Physicians Statement
• Moderate to severe COPD

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Combined interval and strength training	Exercise training	CHF Pts randomly designed at the combined interval and strength training group
Aerobic interval training	Exercise training	CHF Patients that randomly designed to participate at the interval training group

Primary Outcome Measures

Name	Time	Method
Aerobic exercise capacity	3 months

Secondary Outcome Measures

Name	Time	Method
Endothelial function, oxygen kinetics, ventilatory drive	3 months

Trial Locations

Locations (1)

Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, First Critical Care Unit, School of Medicine, National & Kapodistrian University of Athens; 🇬🇷 Athens, Greece