High-intensity Interval Versus Combined Exercise Training in CHF

Not Applicable

• Conditions: Heart Failure
• Interventions: Other: Combined exercise training; Other: High-intensity interval exercise training

• Registration Number: NCT02387411
• Lead Sponsor: University of Athens

Brief Summary

Chronic heart failure (CHF) is a clinical syndrome presented with central, cardiac deterioration as well as peripheral vascular and muscular abnormalities, resulting finally to reduced exercise tolerance, quality of life and mortality rates. Exercise training is a major component of rehabilitation / secondary prevention interventions, inducing significant beneficial changes in mechanisms of pathophysiology, exercise tolerance, functional capacity and quality of life, while a positive impact on hospitalization and mortality reduction should not be also excluded. There has been growing interest in the characteristics and modalities of exercise training able to induce optimal benefits. High intensity and interval mode have been shown to induce greater benefits than moderate intensity and continuous mode regimes. Additionally, there has been sound rationale for the inclusion of strength training, which has been also shown able to yield benefits in terms of exercise capacity and quality of life. However, there haven't been much data on the so called combined regimes, which include both aerobic exercise and strength training. This study aims at investigating the effects of combined high-intensity interval and strength training compared to high-intensity interval exercise alone in CHF.

Detailed Description

Not available

Study Timeline

• Study Start: 2010-05
• Study First Submitted: 2015-02-19
• Status Verified: 2015-03
• Study First Submitted QC: 2015-03-12
• Last Update Submitted: 2015-03-12
• Study First Posted: 2015-03-13
• Last Update Posted: 2015-03-13
• Primary Completion: 2015-06
• Study Completion: 2015-06

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

• stable heart failure
• ejection fraction <=45%
• optimal medical treatment
• NYHA class <=III

Exclusion Criteria

• contraindications for maximal cardiopulmonary exercise testing (CPET)
• moderate to severe COPD
• inability to follow exercise programs due to orthopaedic problems

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Combined group	Combined exercise training	combined exercise training
Interval group	High-intensity interval exercise training	high-intensity interval exercise training

Primary Outcome Measures

Name	Time	Method
aerobic exercise capacity (assessed by cardiopulmonary exercise testing)	3 months

Secondary Outcome Measures

Name	Time	Method
quadriceps cross sectional area (assessed by CT)	3 months
strength exercise capacity (assessed by 1-repetition maximum test)	3 months
quality of life (assessed by MLWHF questionnaire)	3 months
quadriceps local adaptations (assessed by muscle biopsies)	3 months

Trial Locations

Locations (1)

Cardiopulmonary Exercise Testing & Rehabilitation Laboratory, 1st Critical Care Dpt, School of Medicine, University of Athens; 🇬🇷 Athens, Greece