Dexmedetomidine as an Additive for (Ipack)Block in Knee Surgery

Not Applicable

Completed

• Conditions: Knee Surgeries
• Interventions: Drug: Bupivacaine; Drug: Dexmedetomidine

• Registration Number: NCT07058493
• Lead Sponsor: Cairo University

Brief Summary

Dexmedetomidine used as an Additive for Ipack Block in Knee Surgery

Detailed Description

Many types of analgesia used but multimodal analgesia showed best results The interspace between the popliteal artery and capsule of the posterior knee (IPACK) block aims to blockade of sciatic nerve terminal branches for analgesia without motor affection

. (IPACK) block is a motor power sparing procedure that involves injecting local anesthetic into the space between the popliteal artery and the posterior capsule of the knee in order to treat posterior knee pain

Study Timeline

• Study Start: 2024-01-02
• Study First Submitted: 2024-05-05
• Primary Completion: 2024-07-10
• Study Completion: 2024-07-30
• Status Verified: 2025-06
• Study First Submitted QC: 2025-06-30
• Last Update Submitted: 2025-06-30
• Study First Posted: 2025-07-10
• Last Update Posted: 2025-07-10

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 18-60 years
• ASA I, II .patients undergoing knee surgeries.

Exclusion Criteria

• patient Refusal
• bleeding disorders
• skin lesion
• infection
• known allergy
• contradictions of spinal anesthesia

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Arm && Interventions

Group	Intervention	Description
Bupivacaine	Bupivacaine	IPACK block with 20ml bupivacaine 0.25% alone. .
Dexmedetomidine	Dexmedetomidine	IPACK block with 20 ml of bupivacaine 0.25% with dexmedetomidine 100 μg as adjuvant.

Primary Outcome Measures

Name	Time	Method
Visual Analog Scale at rest score during first postoperative 48 hours	48 postoperative hours	Visual Analog Scale at rest during first postoperative 48 hours a line 10centimeters long from zero to10 where 10 is the worst pain ever

Secondary Outcome Measures

Name	Time	Method
Visual Analog Scale at rest and during movement at 30 minuts, 2, 8, 16, 24, 36, and 48 hours	48 postoperative hours	Visual Analog Scale at rest during 48 postoperative hour a line 10centimeters long from zero to10 where 10 is the worst pain ever
Duration of the block	48 hours	Duration of the block
Heart Rate	48 hours	Heart Rate
Mean Arterial Pressure	48 hours	Mean Arterial Pressure
Block performance time in minutes	preoperative	Block performance time in minutes
Incidence of adverse effects	2 hours inPACU	Incidence of adverse effects

Trial Locations

Locations (1)

Faculty of medicine Cairo university; 🇪🇬 Cairo, Egypt