Whether the antioxidants can prevent patients with obstructive jaundice from the hypotension in operation.

Phase 4

• Conditions: obstructive jaundice; vascular hyporesponsiveness; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system; Anaesthesiology - Other anaesthesiology; Oral and Gastrointestinal - Other diseases of the mouth, teeth, oesophagus, digestive system including liver and colon

• Registration Number: ACTRN12611000980932
• Lead Sponsor: Department of Anesthesiology,Easten Hepatobiliary Hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2011-09-14
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: Male
• Target Recruitment: 80

Inclusion Criteria

participants with obstructive jaundice(serum total bilirubin>100umol/L)caused by neoplasm of the bile duct or the head of the pancreas who will undergo abdominal operation

Exclusion Criteria

females,<50 years >70 years,BMI>30kg/m2 <18kg/m2,diabetes,cardiovascular diseases

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
blood pressure from radial artery cannula[every 5 minutes for the duration of the operation];pulmonary arterial wedge pressure from pulmonary artery balloon flow catheter(Swan-ganz catheter)[every 5 minutes for the duration of the operation];heart rate from monitor[every 5 minutes for the duration of the operation]

Secondary Outcome Measures

Name	Time	Method
the expression of alpha-advenergic receptors protein on mesenteric artery by Westen blot[immediately after operation];mRNA expressing alpha-advenergic receptors on mesenteric artery by Real time PCR(Polymerase chain reaction)[immediately after operation]