NL-OMON24362
Not yet recruiting
Not Applicable
Single-cell analysis of somatic mutations to understand and improve hematopoiesis after transplantation
Princess Máxima Center for Pediatric Oncology0 sites20 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Allogeneic hematopoietic stem cell transplantation
- Sponsor
- Princess Máxima Center for Pediatric Oncology
- Enrollment
- 20
- Status
- Not yet recruiting
- Last Updated
- 2 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •(1\) Allogeneic HSCT with bone marrow cells from a healthy sibling donor; (2\) Age at HSCT \<18 yrs; (3\) First HSCT; (4\) Availability of viably frozen donor bone marrow cells from the Biobank of the UMC Utrecht; (5\) \>95% donor chimerism; (6\) No major HSCT\-related complications (see exclusion criteria).
Exclusion Criteria
- •(1\) Major HSCT\-related complications, such as \>grade 2 graft versus host disease; (2\) Secondary graft failure; (3\) Objection to be notified about actionable findings from whole\-genome sequencing; (4\) Failure of the HSCT recipient, donor and/or their legal representatives to understand the patient information and informed consent form (either due to intellectual disability or to language problems). Of note: Only include subjects in whom both the HSCT recipient and his/her donor (and, if applicable, their caregivers) agree to participate in the current study are eligible.
Outcomes
Primary Outcomes
Not specified
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