NL-OMON54736
Completed
Not Applicable
Single-cell analysis of somatic mutations to understand and improve blood formation after hematopoietic stem cell transplantation - Tracing stem cells after transplantation
Prinses Máxima Centrum voor Kinderoncologie0 sites50 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Prinses Máxima Centrum voor Kinderoncologie
- Enrollment
- 50
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Patients (n\=30\):
- •\- Recipients of an allogeneic hematopoietic stem cell transplantation (HSCT)
- •from an umbilical cord blood donor (n\=10\), adult haplo donor (n\=10\), or healthy
- •sibling donor (n\=10\)
- •\- Age at HSCT \<18 yrs
- •\- First HSCT
- •\- \>95% donor chimerism at the time of blood sampling
- •\- Currently alive
- •\- No major HSCT\-related complications (see exclusion criteria),
- •Healthy subjects (n\=20\):
Exclusion Criteria
- •\- Major HSCT\-related complications, such as \>grade 2 graft versus host disease.
- •\- Secondary graft failure
- •\- Objection to be notified about actionable findings from whole\-genome
- •sequencing.
- •\- Failure of the HSCT recipient, donor and/or their legal representatives to
- •understand the patient information and informed consent form (either due to
- •intellectual disability or to language problems). Of note: For sibling and
- •haplo transplants, we will only include subjects in whom both the HSCT
- •recipient and his/her donor (and, if applicable, their caregivers) agree to
- •participate in the current study.
Outcomes
Primary Outcomes
Not specified
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