Single-cell analysis of somatic mutations to understand and improve blood formation after hematopoietic stem cell transplantation - Tracing stem cells after transplantation

Prinses Máxima Centrum voor Kinderoncologie0 个研究点目标入组 50 人开始时间: 待定最近更新: 2024年6月11日

试验速览

暂无简介。

•Patients (n=30):
•- Recipients of an allogeneic hematopoietic stem cell transplantation (HSCT)
•from an umbilical cord blood donor (n=10), adult haplo donor (n=10), or healthy
•sibling donor (n=10)
•- Age at HSCT <18 yrs
•- First HSCT
•- >95% donor chimerism at the time of blood sampling
•- Currently alive
•- No major HSCT-related complications (see exclusion criteria),
•Healthy subjects (n=20):
•- Healthy donors of the sibling and haplo-HSCT recipients described above.

•- Major HSCT-related complications, such as >grade 2 graft versus host disease.
•- Secondary graft failure
•- Objection to be notified about actionable findings from whole-genome
•sequencing.
•- Failure of the HSCT recipient, donor and/or their legal representatives to
•understand the patient information and informed consent form (either due to
•intellectual disability or to language problems). Of note: For sibling and
•haplo transplants, we will only include subjects in whom both the HSCT
•recipient and his/her donor (and, if applicable, their caregivers) agree to
•participate in the current study.

发起方

Prinses Máxima Centrum voor Kinderoncologie