Effct of Rehabilitation in Stroke Recovery

Not Applicable

• Conditions: stroke.; stroke, not specified as haemorrhage or infarction

• Registration Number: IRCT2016102430477N1
• Lead Sponsor: Vice Chancellor of Research, Shiraz University of Medical Science

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 22 February 2018

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

First-ever stroke resulting in right or left upper limb paresis and stroke had occurred between 2 weeks and 3 months; CT or MRI documenting a monohemispheric lesion as determined by a neurologist; Age between 18 and 80 years old; Patients with right-hand dominant according to Edingburg handedness scale; Patients with severe motor deficit of wrist extensor (score of 2 or less in strength test scale); Patients with severe to moderate motor impairment of affected upper limb (points less than 45 in items related to upper limb motor function); Not taking anti-spasticity drugs.
Exclusion criteria:
Other neurological diseases; Presence of pain, fracture, surgical history and joint dislocation of upper extremity; Contraindications to transcranial magnetic stimulation (TMS) including cardiac pacemaker, metal implants in skulls or eye, past history of seizure ; Presence of dementia, severe cognitive impairment (score of less than 24 points on the mini-mental status examination), aphasia and depression that made the patient uncooperative; Current use of drugs that could affect the excitability of the motor cortex, such as anti-epileptic and psychoactive drugs.

Exclusion Criteria

Not provided

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Rest motor threshold. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Active motor threshold. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Recruitment curve. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Cortical silent period. Timepoint: before intervention, after intervention. Method of measurement: TMS device.;Ipsilateral silent period. Timepoint: before intervention, after intervention. Method of measurement: TMS device.

Secondary Outcome Measures

Name	Time	Method
Measuring performance in activities of daily living. Timepoint: before intervention, after intervention. Method of measurement: Modified Barthel Index.;Spasticity. Timepoint: before intervention, after intervention. Method of measurement: modified modified ashworth scale.;Wrist extensor muscle strength. Timepoint: before intervention, after intervention. Method of measurement: isokinetic dynamometer biodex device.;Assessment of motor function. Timepoint: before intervention, after intervention. Method of measurement: Fugl-Meyer Assessment.