Evaluation and comparison of the effect of cross education training of unaffected upper limb on neurophysiological parameters and functional indices of affected upperlimb in sub-acute stroke patients

Vice Chancellor of Research, Shiraz University of Medical Science0 个研究点目标入组 20 人开始时间: 待定最近更新: 2018年2月22日

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•First-ever stroke resulting in right or left upper limb paresis and stroke had occurred between 2 weeks and 3 months; CT or MRI documenting a monohemispheric lesion as determined by a neurologist; Age between 18 and 80 years old; Patients with right-hand dominant according to Edingburg handedness scale; Patients with severe motor deficit of wrist extensor (score of 2 or less in strength test scale); Patients with severe to moderate motor impairment of affected upper limb (points less than 45 in items related to upper limb motor function); Not taking anti-spasticity drugs.
•Exclusion criteria:
•Other neurological diseases; Presence of pain, fracture, surgical history and joint dislocation of upper extremity; Contraindications to transcranial magnetic stimulation (TMS) including cardiac pacemaker, metal implants in skulls or eye, past history of seizure ; Presence of dementia, severe cognitive impairment (score of less than 24 points on the mini-mental status examination), aphasia and depression that made the patient uncooperative; Current use of drugs that could affect the excitability of the motor cortex, such as anti-epileptic and psychoactive drugs.

发起方

Vice Chancellor of Research, Shiraz University of Medical Science