The Effective Dose of Dexmedetomidine for Moderate Sedation of Adult Intubated Septic Patients in the ICU.
Overview
- Phase
- Not Applicable
- Intervention
- Dexmedetomidine
- Conditions
- Sepsis
- Sponsor
- First Affiliated Hospital of Zhejiang University
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Dose of dexmedetomidine
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Septic patients in Intensive Care Unit always need mechanical ventilation and conscious-sedation. But the recommended dose 0.2-0.7μg/kg/h could not run well because of wide range. The purpose of this study is to find the effective dose of dexmedetomidine adult septic patients of mechanical ventilation .
Detailed Description
Inclusion Criteria: Age: between 18 years mechanical ventilation RASS≥2 A diagnosis of sepsis within 48 hours Exclusion Criteria: Cardiac disease Cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users Primary Outcome Measures: Dose of dexmedetomidine Secondary Outcome Measures: RASS score Requirement for rescue intervention, RASS will be recorded per hour.
Investigators
zhanqin zhang
PHD candidate
First Affiliated Hospital of Zhejiang University
Eligibility Criteria
Inclusion Criteria
- •intubated patients RASS≥2 A diagnosis of sepsis within 48h
Exclusion Criteria
- •Cardiac disease Cardiac rhythm abnormalities liver dysfunction coma severe hypotension muscle relaxant users
Arms & Interventions
dexmedetomidine,sepsis,ED50
Intervention Name: dexmedetomidine dosage form: intravenous injection dosage：0.2-0.7μg/kg/h frequency: 1 duration:12 hours
Intervention: Dexmedetomidine
Outcomes
Primary Outcomes
Dose of dexmedetomidine
Time Frame: 12 hours
Secondary Outcomes
- RASS score Requirement for rescue intervention, RASS will be recorded per hour.(1 hour)