Impact of Age and Geriatric Co-morbidities on Lymphocyte Phenotype in Patients 70 Years of Age and Older

Withdrawn

• Conditions: Geriatrics Immunosenescence
• Interventions: Biological: Blood samples; Other: Data collection

• Registration Number: NCT04772092
• Lead Sponsor: Centre Hospitalier Universitaire Dijon

Brief Summary

An individual's immune profile changes with age, and can sometimes be involved in the development of certain diseases such as infections or cancers, in a process called immunosenescence. Some data tend to show that there is a link between this immune profile and geriatric fragility (autonomy, difficulties with walking, memory, undernutrition, co-morbidities, depression). The aim of this study is to describe this profile, or immune phenotype, and to see if there is a link with the different aspects of geriatric assessment in patients without cancer or infection. In addition, these data will serve as a basis for comparison with the same analyses performed on breast cancer patients at the Centre Georges François Leclerc.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2021-02-24
• Study First Submitted QC: 2021-02-24
• Study First Posted: 2021-02-26
• Study Start: 2021-11
• Primary Completion: 2021-11
• Study Completion: 2021-11
• Status Verified: 2022-09
• Last Update Submitted: 2022-09-05
• Last Update Posted: 2022-09-08

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• Person who has not opposed to inclusion in the study
• Male or female aged 70 and over admitted to the Champmaillot Geriatric Center on an inpatient or outpatient basis.

Exclusion Criteria

• Person not affiliated to national health insurance system
• Person subject to a measure of legal safeguard (curatorship, etc)
• Person with an acute infection
• Person with suspected cancer or active cancer
• Long-term immunosuppressive or corticosteroid therapy
• HIV and/or HBV and/or HCV positive serology

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Seniors	Data collection	70 years of age and over, inpatients or outpatients
Seniors	Blood samples	70 years of age and over, inpatients or outpatients

Primary Outcome Measures

Name	Time	Method
percentage of immune cells in peripheral blood	At inclusion	technique used: flow cytometry