Leucine Supplementation Strategies to Enhance Muscle Anabolic Responses in Older Age

Not Applicable

Recruiting

• Conditions: Muscle Protein Synthesis

• Registration Number: NCT06567665
• Lead Sponsor: University of Nottingham

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2024-8-20
• Last Update Posted: 2 September 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Male
• Target Recruitment: 10

Inclusion Criteria

Inclusion Criteria:<br><br> - Male, 65-75 years of age<br><br> - BMI 18-28 kg/m2<br><br> - Non smoker<br><br> - Not performing regular resistance type exercise<br><br> - Participant is willing and able to give informed consent for participation in the<br> study<br><br>Exclusion Criteria:<br><br> - A BMI <18 or >28 kg·m-2<br><br> - Active cardiovascular disease: uncontrolled hypertension (BP > 160/100), angina,<br> heart failure (class III/IV), arrhythmia, right to left cardiac shunt or recent<br> cardiac event<br><br> - Cerebrovascular disease: previous stroke, aneurysm (large vessel or intracranial)<br><br> - Respiratory disease including pulmonary hypertension or chronic obstructive<br> pulmonary disease (COPD)<br><br> - Metabolic disease: hyper and hypo parathyroidism, untreated hyper and<br> hypothyroidism, Cushing's disease, types 1 or 2 diabetes (treated and untreated),<br> inborn/ congenital errors of metabolism (e.g. phenylketonuria (PKU), galactosaemia)<br><br> - Active inflammatory bowel disease<br><br> - Acute infection<br><br> - Acute or chronic renal disease<br><br> - Malignancy (or history of malignancy with 5 y)<br><br> - Recent steroid treatment (within 6 mo), or hormone replacement therapy<br><br> - Coagulopathy<br><br> - Musculoskeletal or neurological disorders<br><br> - Known allergies to any of the product ingredients<br><br> - Having taken part in a research study in the last 3 months involving invasive<br> procedures or an inconvenience allowance

Exclusion Criteria

Not provided

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Muscle protein synthesis in response to leucine feeding

Secondary Outcome Measures

Name	Time	Method
Measure muscle anabolic and catabolic signalling pathways in response to leucine feeding