PROMO: Protein Supplementation to Improve Muscle Mass in Malnourished Elderly via Oral Nutritional Supplements.
- Conditions
- MalnutritionSarcopenia10028302
- Registration Number
- NL-OMON42973
- Lead Sponsor
- Wageningen Universiteit
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 82
Age *65 y
Malnourished/at risk of malnourishment as screened by MNA (Score range 0 * 11)
Mental status that is incompatible with the proper conduct of the study
Illness of such severity that life expectancy is considered to be less than 12 months
Use of diabetes medication (e.g. insulin, metformin), corticosteroïds, or antibiotics
Use of over 20 portions of oral nutritional supplements in the previous month or over 10 in the previous week
Participating in any regular exercise training program (*2h/w)
Renal insufficiency (eGFR <30 mL/min/1.73 m2)
Recent blood donation or change in medication use
Allergic or sensitive for milk proteins or veganistic lifestyle
When participating in the muscle biopsies use of anticoagulants is not permitted.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Our main interest is in the mean differences in change in body weight (kg) and<br /><br>lean body mass (kg) between treatment 1 vs. treatment 2.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Physical performance<br /><br>Muscle health<br /><br>Immune function<br /><br>Physical activity<br /><br>Dietary intake<br /><br>Muscle fibre hypertrophy<br /><br>Compliance</p><br>