Protein supplementation and exercise training to increase muscle protein synthesis rates in patients with advanced chronic kidney disease

Recruiting

Conditions: Skeletspier aandoeningen
muscle mass
muscle protein synthesis
Sarcopenia
10029149

Registration Number: NL-OMON56016

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 62

Inclusion Criteria

1. In order to be eligible to participate in this study, a patient with CKD
must meet all of the following criteria:
• (e)glomerular filtration rate (GFR) <45 ml/min/1.73m2
• Age: 18 - 80 y
• Able to provide written informed consent

2. In order to be eligible to participate in this study, a healthy subject must
meet all of the following criteria:
• (e)GFR >60 ml/min//1.73m2 without albuminuria
• Age: 18 - 80 y
• Able to provide written informed consent

Exclusion Criteria

• Insulin-dependent diabetes mellitus or two or more oral glucose lowering
medications
• Active inflammatory disease / malignancies
• Uncontrolled hypertension (>160/100mm Hg), unstable angina pectoris, or
arrhythmia
• Pulmonary disease restricting exercise performance (e.g. COPD)
• A history of neuromuscular problems
• Cognitive Impairment
• Diagnosed GI tract diseases / dysphagia
• Allergies to milk proteins / Lactose intolerance
• Pregnancy
• Hospitalization <1 months prior to study period
• Participation in any structured exercise program
• Any medications known to affect protein metabolism (i.e. corticosteroids or
prescription strength acne medications).
• Use of DOAC, vitamin-K-antagonist, or multiple anticoagulants.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary outcomes in this study will be daily muscle protein synthesis rates<br /><br>as measured by the deuterated water method. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters include muscle mitochondrial bioenergetics, muscle<br /><br>fiber size, leg lean mass, and aerobic capacity muscle mitochondrial<br /><br>bioenergetics, saliva 2H enrichment, food intake, and physical activity<br /><br>levels.at baseline.</p><br>