ProMuscle, A protein supplementation and exercise strategy to promote muscle protein anabolism in frail elderly people
Completed
- Conditions
- Sarcopenia10028302
- Registration Number
- NL-OMON33401
- Lead Sponsor
- TIF
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 120
Inclusion Criteria
• Elderly people: > 65 years
• frail elderly individuals (based on MNA, CES-D Depression Scale and physical
inactivity)
• Male and female
• Able to understand and perform the study procedures
Exclusion Criteria
•• Type I or type II diabetes (fasted blood glucose level >=7,0)
• No recent history (within 2 years) of participating in any regular resistance exercise training program (general questionnaire)
• Use of anti-coagulation medication (except of Acetyl Salicyl acid)
• Presence of coronary heart disease (ECG)
• Renal insufficiency (creatinine level > 200 mmol/l)
• High blood pressure (>160 mm Hg systolic)
• Allergic or sensitive for milk proteins
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary outcome measure of this study will be change in skeletal muscle<br /><br>mass after the 6 month intervention.</p><br>
- Secondary Outcome Measures
Name Time Method <p>Physical function<br /><br>Musclefibre hypertrophy<br /><br>Intracellulair protein synthesis pathways<br /><br>Nitrogen balance<br /><br>3-methylhistidine<br /><br>Nutritional intake<br /><br>Physical Activity measurement<br /><br>Cognitive functioning<br /><br>Depression<br /><br>Bloodpressure</p><br>