The effects of protein ingestion and exercise on plasma and dialysate amino acid concentrations during hemodialysis

Completed

• Conditions: Amino acid loss during hemodialysis; 10003018; hemodialysis; 10038430

• Registration Number: NL-OMON48888
• Lead Sponsor: Medisch Universitair Ziekenhuis Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 15 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 23

Inclusion Criteria

- Aged >18 years
- Ability to provide written informed consent
- Hemodialysis treatment for >3 months
- Well-functioning arteriovenous shunt in upper or lower arm

Exclusion Criteria

- Unstable cardiac status (i.e. cardiac ischemia)
- Physical limitations affecting usage of the bike
- Poor blood sugar control
- Active infection or illness
- Poorly functioning shunt
- Previous episodes of intradialytic hypotension related to food intake
- Hospitalization <3 months prior to study period
- Missed hemodialysis session <1 month prior to study period
- Allergies to milk protein

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Primary study parameters are amino acid loss into the dialysate and plasma<br /><br>total amino acid concentrations. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters are the loss of essential amino acids into the<br /><br>dialysate, plasma essential amino acid, glucose, and insulin concentrations,<br /><br>interstitial glucose concentrations, and changes in blood pressure.</p><br>