The effects of protein ingestion to maximize endurance-based training adaptations in untrained healthy young me

Withdrawn

• Conditions: Effect van duurtraining en eiwit op spier en bloed; Not applicable

• Registration Number: NL-OMON43095
• Lead Sponsor: Wageningen Universiteit

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 44

Inclusion Criteria

Male
* Age between 18 and 30 years of age
* BMI between 18.5 * 25 kg/m2
* VO2max 50 of lager
* Recreationally active, performing sports on a non-competitive basis
* Willing to give muscle biopsies
* Willing to give blood samples
* No use of antibiotics in the past month
* No use of illicit drugs
* Suitable veins for blood withdrawal
* Registered by a general-practitioner
* Consumption of alcohol beverages is less than 21 per week
* No blood donor during the study
* Able to be present and all university visits
* Able to perform three exercise sessions weekly for 12 weeks
* Not employed, or intern, or working on thesis at the department of Human Nutrition at Wageningen University
* Not participating in another scientific study (except EetMeetWeet)
* Able to participate during the experimental days en pre tests

Exclusion Criteria

* Medical condition that can interfere with the study outcome (i.e. cardiovascular disease, pulmonary disease, lactose and gluten intolerance)
* Use of medications known to interfere with selected outcome measures (i.e. statins, fenofibrate)
* Use of antithrombotic therapy (marcoumar, sintromitis, clopidogrel and NOAC*s).
* Diagnosed with liver disease
* Diagnosed diabetes mellitus type 1 or 2
* (Chronic) injuries of the locomotor system that can interfere with the intervention
* Participants with a recent history or current state of COPD
* Participants with a recent history or current state of rheumatoid arthritis
* Participants with a recent history or current state of musculoskeletal/orthopedic disorders
* Participants with a recent history or current state of renal disorder
* Participants with a recent history or current state of cognitive impairment
* Participants with orthopedic metal implants in the spine and/or upper/lower extremities
* Participants with lactose intolerance and/or dairy protein allergy
* Participants who are enrolled in an interventional biomedical research project or have received an investigational new drug or product with the last 30 days prior to screening.
* Participants on medication, including anticoagulants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>VO2max (maximal oxygen consumption during exercise)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Time trial (bicycle ergometer)<br /><br><br /><br>1RM strength (1RM leg press / Bio-dex)<br /><br><br /><br>Quadriceps cross sectional area (MRI)<br /><br><br /><br>Whole body and regional body composition (DXA-scan)<br /><br><br /><br>Muscle fibre type specific distribution (muscle biopsy)<br /><br><br /><br>Mitochondrial mass (muscle biopsy)<br /><br><br /><br>Mitochondrial function (muscle biopsy)<br /><br><br /><br>Haemoglobin mass (blood)<br /><br><br /><br>Cardboxyhaemoglobin (blood)<br /><br><br /><br>Haematocrit (blood)<br /><br><br /><br>Red blood cell volume (blood)<br /><br><br /><br>Plasma volume (blood)<br /><br><br /><br>Body mass index (BMI)<br /><br><br /><br>Waist circumference<br /><br><br /><br>Leg volume</p><br>