The impact of protein supplementation to maximize the skeletal muscle adaptive response to resistance type exercise training in healthy elderly me

Completed

• Conditions: Aging - Sarcopenia; Muscle loss; Sarcopenia; 10028302

• Registration Number: NL-OMON44031
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 28 February 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 46

Inclusion Criteria

* Healthy males
* Age between 65 and 80 y
* BMI between 18.5 and 30 kg/m2
* Moderately active, performing fitness or sports on a non-competitive basis 1 time or less than 2 hours per week

Exclusion Criteria

* HbA1C level above 6.5%
* Fasted blood glucose level above 6.9 mmol/L
* Celiac disease
* Lactose intolerance
* Smoking
* Diabetes
* Cancer
* Cardiovascular Disease
* Diagnosed GI tract diseases
* Arthritic conditions
* A history of neuromuscular problems
* Cognitive Impairment
* COPD
* Renal disorder
* Any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).
* Participation in exercise program
* Hypertension, high blood pressure that is above 140/90 mmHg.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quadriceps CSA (CT Scan)</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>* Skeletal muscle fibre size (Muscle Biopsy)<br /><br>* Whole-body and regional body composition (DEXA)<br /><br>* Muscular strength (1 RM * each exercise machine)<br /><br>* Diurnal rates of muscle protein synthesis (Muscle Biopsy - Heavy water)</p><br>