The impact of dietary protein supplementation and age on muscle mass loss during short term one-legged knee immobilizatio

Completed

• Conditions: muscle metabolism; disuse atrophy; 10037008; 10028302

• Registration Number: NL-OMON37842
• Lead Sponsor: niversiteit Maastricht

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 29 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

Male
Aged from 18-35 years and from 65-75 years
18.5 < BMI < 30 kg/m2

Exclusion Criteria

Smoking
Performing regular resistance training in the previous 6 months
Hypertension (according to WHO criteria) and/or cardiovascular disease
Any back/leg/knee/shoulder complaints which may interfere with the use of crutches
Systemic use of antibiotics within 3 weeks prior to the study visit
Current systemic use of corticosteroids, growth hormone, testosterone, immunosuppressants or insulin
Type 2 diabetes mellitus
Any family history of thrombosis
All co-morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthritis, spasticity/rigidity, all neurological disorders and paralysis)
Myocardial infarction within the last 3 years
Use of anti-coagulants

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Quadriceps cross sectional area (CSA). </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Leg lean mass, type I and II muscle fiber CSA and satellite cell content,<br /><br>muscle strength, mRNA and protein expression of anabolic signaling proteins.</p><br>