The effect of standard or higher protein feeding on indicator amino acid oxidation in ICU patients

Conditions: Eiwitbehoefte
Protein requirement
Need for protein

Registration Number: NL-OMON53266

Lead Sponsor: niversiteit Maastricht

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Pending

Sex: Not specified

Target Recruitment: 8

Inclusion Criteria

• >= 18 years old
• Unplanned admission to the ICU
• Mechanically ventilated
• Start of enteral nutrition within 2 days of intubation
• >= 3 days on enteral nutrition
• Expected remaining ICU stay on mechanical ventilation of >= 2 days

Exclusion Criteria

• Contra-indication for enteral nutrition at the discretion of the treating
physician • Feeding intolerance during incremental feeding protocol • Moribund
or withholding of treatment • On extracorporeal membrane oxygenation (ECMO) •
Presence of chest drains, pneumothorax, tracheoesophageal fistula or
subcutaneous emphysema • Kidney failure AND a *no dialysis*-code on admission •
Hepatic encephalopathy (West Haven criteria 3-4) • BMI < 18 kg/m2

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The primary endpoint is indicator amino acid oxidation after enteral feeding<br /><br>with a standard or higher protein content, determined using the Indicator Amino<br /><br>Acid Oxidation (IAAO) method by measuring 13CO2 enrichment in expired breath<br /><br>and enrichment of L-[1-13C]-phenylalanine in plasma and urine.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>To determine carbon dioxide production, 13CO2 production, plasma and urine<br /><br>L-[1-13C]-phenylalanine enrichments, plasma phenylalanine concentration, and<br /><br>fecal output and protein content in ICU patients when applying the IAAO<br /><br>technique.</p><br>