Effects of Melatonin on injury caused by transplant process in renal transplant patients
Not Applicable
- Conditions
- Kidney Transplant.Kidney transplant status
- Registration Number
- IRCT201610203812N5
- Lead Sponsor
- Vice Chancellor for Research of Tabriz University of Medical Sciences, Biotechnology Research Center
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 80
Inclusion Criteria
kidney transplant candidate? had a history of dialysis at least 3 months.
Exclusion criteria :Patients with inflammatory disease? acute or chronic infection? autoimmune diseases? hepatic insufficiency ? diabetes? malignancy ?depression ? high and low pressure ? seizures ? smokers
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method TNF-a. Timepoint: 3 month. Method of measurement: ELISA.;Nulear NFKB activity. Timepoint: 3 month. Method of measurement: ELISA.;Oxidative stress factors. Timepoint: 3 month. Method of measurement: spectrophotometric methods.
- Secondary Outcome Measures
Name Time Method Klotho gene and protein expression. Timepoint: 3 month. Method of measurement: Real-time PCR and western blotting.