MRI-Linac treatment for radiotherapy patients. A study on the use of the Australian MRI-Linac to treat cancer radiotherapy patients

Not Applicable

• Conditions: Cancer requiring palliative radiotherapy; Cancer - Any cancer

• Registration Number: ACTRN12621000418875
• Lead Sponsor: South Western Sydney Local Health District

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-04-15
• Last Update Posted: 7 November 2022

Recruitment & Eligibility

• Status: ot yet recruiting
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

18 years or older
- Have the ability to give informed consent with the clear understanding that this is a prototype cancer radiation therapy system and not a commercially available and supported system
- A diagnosis of cancer with a palliative indication for radiotherapy and referral to the Liverpool or Macarthur Cancer Therapy Centres
- A treatment site and prognosis that, in the opinion of the treating physician, is clinically appropriate for this MRI-Linac feasibility trial using conformal radiotherapy in consultation with medical physicists and radiation therapists. The treatment fields used for planning must be able to be accommodated for the particular patient on the MRI-Linac. Examples may include (but are not restricted to) patients presenting with:
- Cervical-spine metastasis
- Whole brain
- Recurrent brain metastasis
- Bone metastasis
- Soft tissue metastasis
- ECOG status 0-2

Exclusion Criteria

- Pain in the treatment position.
- Resources not available to reasonably expect to commence treatment within two weeks of consent
- Patient unable to physically fit into the MRI-Linac patient treatment space
- Contraindication to MRI as according to departmental protocol.
- Contraindication to standard radiation therapy
- Pregnant women

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Feasibility will be assessed by quantifying the proportion of patients for whom treatment is successfully conducted. If 6 or more out of 10 patients complete all of their treatment sessions on the MRI-Linac, then we will have demonstrated feasibility. If 5 or fewer out of 10 patients complete all of their treatment sessions then we will conclude that MRI-Linac radiotherapy is not currently feasible with the Australian MRI-Linac device. All relevant records will be noted in the patients’ medical records, including whether treatment was fully or partially completed on the MRI-Linac.[Feasibility will be assessed after all participants have either attempted or fully completed their treatment sessions on the MRI-Linac, prior to study closure.]