Study of uterine arteries changes in effect of Magnesium-Sulfate in severe pre-eclamptic women and situation of this mother's infants
Phase 2
- Conditions
- pre-eclampsia.Severe pre-eclampsia
- Registration Number
- IRCT201108157341N1
- Lead Sponsor
- Vice chancellor for research, Kermanshah University of Medical Sciences and Health Services
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Female
- Target Recruitment
- 20
Inclusion Criteria
severe pre-eclamptic G1 (first pregnancy) women with gestational age over 28 weeks and any of following situation: systolic blood pressure over 16 mmHg, diastolic blood pressure over 110 mmHg, constant proteinuria 2+ and over, liver enzyme rise over 1.5 times over the normal range, headache, impaired vision, epigastric pain, oliguria, serum creatinine value over 0.9, fetal intra-uterine-growth-retardation (IUGR), pulmonary edema, low platelets less than 100,000. Exclusion criteria: any systemic disease (diabetes, history of hypertension, autoimmune disease); smoking history; opium and drugs use.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Changes of uterine artery blood flow. Timepoint: before and after magnesium-sulfate injection. Method of measurement: Color-Doppler Sonography.
- Secondary Outcome Measures
Name Time Method Infant's apgar. Timepoint: in 1st and 5th seconds of birth. Method of measurement: standard apgar measurment.;Infan's weight. Timepoint: imediately after birth. Method of measurement: with digital scale (Vore).;NICU requirement. Timepoint: till 3 days after birth. Method of measurement: addmiition in any reasons.