A Study of the Efficacy and Safety of Guselkumab in Participants With Moderately to Severely Active Crohn's Disease
- Conditions
- Crohn's Disease
- Interventions
- Registration Number
- NCT03466411
- Lead Sponsor
- Janssen Research & Development, LLC
- Brief Summary
The purpose of this study is to evaluate the clinical efficacy (GALAXI 1), clinical and endoscopic efficacy (GALAXI 2 and GALAXI 3) and safety of guselkumab in participants with Crohn's disease.
- Detailed Description
This program consists of 3 separate studies: a 48-week Phase 2 dose-ranging study (GALAXI 1) and two 48-week Phase 3 confirmatory studies (GALAXI 2 and GALAXI 3). In Phase 2, safety and efficacy of guselkumab dose regimens will be evaluated to support the selection of induction and maintenance dose regimens for confirmatory evaluation in Phase 3. Participants who complete the 48-week Phase 2 or Phase 3 studies may be eligible to enter the long term extension (LTE). Throughout the 3 studies, efficacy, pharmacokinetic, biomarkers, and safety will be assessed.
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1409
- Have Crohn's disease (CD) or fistulizing Crohn's disease of at least 3 months duration (defined as a minimum of 12 weeks), with colitis, ileitis, or ileocolitis, confirmed at any time in the past by radiography, histology, and/or endoscopy
- Have moderate to severe CD as assessed by CDAI, stool frequency (SF), and abdominal pain (AP) scores, and Simple Endoscopic Score for Crohn's Disease (SES-CD)
- Have screening laboratory test results within the protocol specified parameters
- A female participant of childbearing potential must have a negative urine pregnancy test result at screening and baseline
- Demonstrated intolerance or inadequate response to conventional or to biologic therapy for CD
- Current diagnosis of ulcerative colitis or indeterminate colitis
- Has complications of Crohn's disease, such as symptomatic strictures or stenoses, short gut syndrome, or any other manifestation
- Unstable doses of concomitant Crohn's disease therapy
- Receipt of Crohn's disease approved biologic agents, investigational agents, or procedures outside of permitted timeframe as specified in the protocol
- Any medical contraindications preventing study participation
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Phase 2 (GALAXI 1): Group 1 (Guselkumab) Guselkumab Dose 1 Participants will receive guselkumab (Dose 1) by intravenous (IV) infusion, followed by guselkumab (Dose 2) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the Long-Term Extension (LTE) phase and continue to receive guselkumab. Phase 2 (GALAXI 1): Group 1 (Guselkumab) Guselkumab Dose 2 Participants will receive guselkumab (Dose 1) by intravenous (IV) infusion, followed by guselkumab (Dose 2) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the Long-Term Extension (LTE) phase and continue to receive guselkumab. Phase 2 (GALAXI 1): Group 2 (Guselkumab) Guselkumab Dose 2 Participants will receive guselkumab (Dose 3) by intravenous (IV) infusion, followed by guselkumab (Dose 2) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. Phase 2 (GALAXI 1): Group 2 (Guselkumab) Guselkumab Dose 3 Participants will receive guselkumab (Dose 3) by intravenous (IV) infusion, followed by guselkumab (Dose 2) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. Phase 2 (GALAXI 1): Group 3 (Guselkumab) Guselkumab Dose 5 Participants will receive guselkumab (Dose 4) by intravenous (IV) infusion, followed by guselkumab (Dose 5) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. Phase 2 (GALAXI 1): Group 3 (Guselkumab) Guselkumab Dose 4 Participants will receive guselkumab (Dose 4) by intravenous (IV) infusion, followed by guselkumab (Dose 5) by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. Phase 2 (GALAXI 1): Group 4 (Ustekinumab) Ustekinumab Participants will receive ustekinumab by intravenous (IV) infusion, followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue ustekinumab may enter the LTE and continue to receive ustekinumab. Phase 2 (GALAXI 1): Group 5 (Placebo/Ustekinumab) Ustekinumab Participants will receive placebo administered by intravenous (IV) infusion. At Week 12, non-responders will receive active treatment (Ustekinumab) administered by intravenous (IV) infusion followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue placebo/ustekinumab may enter the LTE and continue to receive placebo/ustekinumab. Phase 2 (GALAXI 1): Group 5 (Placebo/Ustekinumab) Placebo Participants will receive placebo administered by intravenous (IV) infusion. At Week 12, non-responders will receive active treatment (Ustekinumab) administered by intravenous (IV) infusion followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue placebo/ustekinumab may enter the LTE and continue to receive placebo/ustekinumab. Phase 3 (GALAXI 2 and 3): Group 1 and Group 2 (Guselkumab) Guselkumab Participants will receive guselkumab by intravenous (IV) infusion, followed by guselkumab by subcutaneous (SC) injection. Participants who are eligible and willing to continue guselkumab may enter the LTE phase and continue to receive guselkumab. Phase 3 (GALAXI 2 and 3): Group 3 (Ustekinumab) Ustekinumab Participants will receive ustekinumab by intravenous (IV) infusion, followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue ustekinumab may enter the LTE phase and continue to receive ustekinumab. Phase 3 (GALAXI 2 and 3): Group 4 (Placebo/Ustekinumab) Ustekinumab Participants will receive placebo administered by intravenous (IV) infusion. At Week 12, non-responders will receive active treatment (ustekinumab) administered by intravenous (IV) infusion followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue placebo/ustekinumab may enter the LTE and continue to receive placebo/ustekinumab. Phase 3 (GALAXI 2 and 3): Group 4 (Placebo/Ustekinumab) Placebo Participants will receive placebo administered by intravenous (IV) infusion. At Week 12, non-responders will receive active treatment (ustekinumab) administered by intravenous (IV) infusion followed by subcutaneous (SC) injection. Participants who are eligible and willing to continue placebo/ustekinumab may enter the LTE and continue to receive placebo/ustekinumab.
- Primary Outcome Measures
Name Time Method Phase 2: Change from Baseline in the Crohn's Disease Activity Index (CDAI) Score at Week 12 Baseline and Week 12 The CDAI score will be assessed by collecting information on 8 different Crohn's disease-related variables, with scores ranging from 0 to approximately 600. A decrease over time indicates improvement in disease activity.
Phase 3: Clinical Response at Week 12 and Clinical Remission at Week 48 Baseline to Week 48 Clinical response and clinical remission based on CDAI score.
Phase 3: Clinical Response at Week 12 and Endoscopic Response at Week 48 Baseline to Week 48 Clinical response based on CDAI score and endoscopic response based on Simple Endoscopic Score for Crohn's Disease (SES-CD).
- Secondary Outcome Measures
Name Time Method Phase 2: Clinical Remission at Week 12 Week 12 Clinical remission is defined as CDAI score \<150.
Phase 2: Clinical Response at Week 12 Week 12 Clinical response is defined as \>= 100-point reduction from baseline in CDAI score or CDAI score \<150.
Phase 2 and Phase 3: Patient-Reported Outcome (PRO)-2 Remission at Week 12 Week 12 PRO-2 remission is defined based on average daily stool frequency (SF), average daily abdominal pain (AP) score and no worsening of AP or SF from baseline.
Phase 2: Clinical-Biomarker Response at Week 12 Week 12 Clinical-biomarker response is defined using clinical response based on the CDAI score and reduction from baseline in C-reactive protein (CRP) or fecal calprotectin.
Phase 2: Endoscopic Response at Week 12 Week 12 Endoscopic Response is measured by the SES-CD. The SES-CD is based on the evaluation of 4 endoscopic components across 5 ileocolonic segments, with a total score ranging from 0 to 56.
Phase 3: Clinical Response at Week 4 Week 4 Clinical response based on CDAI score.
Phase 3: Clinical Remission at Week 12 Week 12 Clinical remission based on CDAI score.
Phase 3: Endoscopic Response at Week 12 Week 12 Endoscopic response based on SES-CD score.
Phase 3: Fatigue Response at Week 12 Week 12 Fatigue response will be based on the Patient-Reported Outcomes Measurement Information System (PROMIS).
Phase 3: Clinical Remission at Week 12 and Endoscopic Response at Week 12 Week 12 Clinical remission based on CDAI score and endoscopic response based on SES-CD score.
Phase 3: Endoscopic Remission at Week 12 Week 12 Endoscopic remission based on SES-CD score.
Phase 3: Clinical Response at Week 12 and Corticosteroid-Free Clinical Remission at Week 48 Baseline to Week 48 Clinical response based on CDAI score; corticosteroid-free clinical remission based on CDAI score and corticosteroid concomitant medications.
Phase 3:Clinical Response at Week 12 and Endoscopic Remission at Week 48 Baseline to Week 48 Clinical response based on CDAI and endoscopic remission based on SES-CD.
Phase 3: Clinical Remission at Week 48 Week 48 Clinical remission based on CDAI score.
Phase 3: Endoscopic Response at Week 48 Week 48 Endoscopic response based on SES-CD.
Phase 3: Clinical Remission at Week 48 and Endoscopic Response at Week 48 Week 48 Clinical remission based on CDAI score and endoscopic response based on SES-CD score.
Phase 3: Endoscopic Remission at Week 48 Week 48 Endoscopic remission based on SES-CD score.
Phase 3: Deep Remission at Week 48 Week 48 Deep remission is defined as clinical remission and endoscopic remission.
Trial Locations
- Locations (569)
Digestive Health Specialists of the Southeast
🇺🇸Dothan, Alabama, United States
Morehouse School of Medicine
🇺🇸Atlanta, Georgia, United States
Houston Methodist Hospital
🇺🇸Houston, Texas, United States
CliniCore Houston
🇺🇸Houston, Texas, United States
US Digestive Health
🇺🇸Wyomissing, Pennsylvania, United States
Homestead Associates in Research Inc
🇺🇸Miami, Florida, United States
Community Research Foundation, Inc.
🇺🇸Miami, Florida, United States
Visionary Investigators Network
🇺🇸Miami, Florida, United States
IU Health University Hospital
🇺🇸Indianapolis, Indiana, United States
Centre Hospitalier de la Cote Basque
🇫🇷Bayonne, France
ISCARE a.s.
🇨🇿Praha 9, Czechia
Rambam Medical Center
🇮🇱Haifa, Israel
Yuaikai Tomishiro Central Hospital
🇯🇵Tomishiro, Japan
Clinical Applications Laboratories, Inc
🇺🇸San Diego, California, United States
Las Vegas Medical Research
🇺🇸Las Vegas, Nevada, United States
Paul Wallace MD
🇺🇸Beverly Hills, California, United States
Pioneer Research Solutions Inc.
🇺🇸Coconut Creek, Florida, United States
SIH Research
🇺🇸Kissimmee, Florida, United States
Harmony Medical Research Institute, Inc.
🇺🇸Hialeah, Florida, United States
Allameh Medical Corp
🇺🇸Mission Viejo, California, United States
Florida Research Center Inc.
🇺🇸Lakewood Ranch, Florida, United States
Atlanta Gastroenterology Associates
🇺🇸Atlanta, Georgia, United States
Clinnova Research
🇺🇸Orange, California, United States
Central Florida Internists
🇺🇸Saint Cloud, Florida, United States
Atlanta Gastroenterology Specialists PC
🇺🇸Suwanee, Georgia, United States
Internal Medicine Center
🇺🇸Mobile, Alabama, United States
Emory University
🇺🇸Atlanta, Georgia, United States
Inland Empire Liver Foundation
🇺🇸Rialto, California, United States
Theia Clincial Research, LLC
🇺🇸Saint Petersburg, Florida, United States
Care Access Research
🇺🇸New York, New York, United States
Onsite Clinical Solutions
🇺🇸Charlotte, North Carolina, United States
Charlotte Gastroenterology and Hepatology, PLLC
🇺🇸Charlotte, North Carolina, United States
Irmandade da Santa Casa da Misericórdia de Santos
🇧🇷Santos São Paulo, Brazil
LSUHSC Shreveport Feist-Weiller Cancer Center
🇺🇸Shreveport, Louisiana, United States
Gastroenterology Associates
🇺🇸Baton Rouge, Louisiana, United States
Elite Research Network - Nature Coast Clinical Research, LLC
🇺🇸Inverness, Florida, United States
Atlanta Center For Gastroenterology
🇺🇸Decatur, Georgia, United States
Huron Gastroenterology Associates Center for Digestive Care
🇺🇸Ypsilanti, Michigan, United States
Atlantic Digestive Health Institute/ Atlantic IBD Center
🇺🇸Morristown, New Jersey, United States
Sanchez Clinical Research, Inc
🇺🇸Miami, Florida, United States
Gastroenterology Consultants
🇺🇸Roswell, Georgia, United States
Louisiana Research Center, LLC
🇺🇸Shreveport, Louisiana, United States
A1 Clinical Research
🇺🇸Jackson Heights, New York, United States
Asheville Gastroenterology Associates
🇺🇸Asheville, North Carolina, United States
Grodno University Hospital
🇧🇾Grodno, Belarus
Care Access Research, Kinston
🇺🇸Kinston, North Carolina, United States
Synergy Clinical Research
🇺🇸Saint Petersburg, Florida, United States
Cleveland Clinic Florida
🇺🇸Weston, Florida, United States
Houston Digestive Diseases Consultants
🇺🇸Houston, Texas, United States
Woodholme Gastroenterology Associates
🇺🇸Baltimore, Maryland, United States
Gastroenterology Associates P.A.
🇺🇸Greenville, South Carolina, United States
Ohio State University
🇺🇸Columbus, Ohio, United States
Tennessee State University
🇺🇸Johnson, Tennessee, United States
Carle Foundation Hospital
🇺🇸Urbana, Illinois, United States
Cumberland Research Associates
🇺🇸Fayetteville, North Carolina, United States
Great Lakes Gastroenterology Research, LLC
🇺🇸Mentor, Ohio, United States
Texas Digestive Disease Consultants
🇺🇸Southlake, Texas, United States
New York Gastroenterology Associates
🇺🇸New York, New York, United States
Baylor Scott and White Research Institute
🇺🇸Temple, Texas, United States
Northshore Gastroenterology Research, LLC
🇺🇸Westlake, Ohio, United States
DHAT Research Institute
🇺🇸Garland, Texas, United States
Northwest Gastroenterology Associates - USA
🇺🇸Bellevue, Washington, United States
Gomel Regional Clinical Hospital
🇧🇾Gomel, Belarus
L2IP Instituto de Pesquisas Clinicas
🇧🇷Brasilia, Brazil
Centro de Estudos Clínicos do Interior Paulista - CECIP
🇧🇷Jau, Brazil
Texas Gastroenterology Associates - Research
🇺🇸Spring, Texas, United States
Clinical Inquest Center, LTD
🇺🇸Beavercreek, Ohio, United States
Concord Hospital
🇦🇺Concord, Australia
Tyler Research Institute, LLC
🇺🇸Tyler, Texas, United States
Gastro One
🇺🇸Germantown, Tennessee, United States
Gastroenterology Consultants of Southwest Virginia
🇺🇸Roanoke, Virginia, United States
Nepean Hospital
🇦🇺Penrith, Australia
MK Blumenau Pesquisa Clínica
🇧🇷Blumenau, Brazil
Instituto Mederi de Pesquisa e Saude
🇧🇷Passo Fundo, Brazil
Universidade Estadual Paulista 'Julio De Mesquita Filho'
🇧🇷Botucatu, Brazil
Monash Health, Monash Medical Centre
🇦🇺Clayton, Australia
Gastroenterology Associates of Tidewater
🇺🇸Chesapeake, Virginia, United States
The Alfred Hospital
🇦🇺Prahran, Australia
Pesquisare Saude
🇧🇷Santo Andre, Brazil
Princess Alexandra Hospital
🇦🇺Woolloongabba, Australia
Hepato-gastroenterologie HK, s.r.o.
🇨🇿Hradec Kralove, Czechia
Universidade Federal do Rio de Janeiro - Faculdade de Medicina
🇧🇷Rio de Janeiro, Brazil
Sociedade Campineira de Educacao e Instrucao Hospital e Maternidade Celso Pierro
🇧🇷Campinas, Brazil
MUHC Montreal General Hospital
🇨🇦Montreal, Quebec, Canada
Praxis pesquisa médica
🇧🇷Santo Andre, Brazil
Inst Goiano Gastroenterologia e Endoscopia Digest Ltda - Clinica de Gastro
🇧🇷Goiania, Brazil
Hospital Nossa Senhora Das Gracas
🇧🇷Curitiba, Brazil
Mount Sinai Hospital-Toronto
🇨🇦Toronto, Ontario, Canada
BR Trials
🇧🇷Sao Paulo, Brazil
Hospital Santa Izabel
🇧🇷Salvador, Brazil
Columbia Gastroenterology
🇨🇦New Westminster, British Columbia, Canada
Fundacao Universidade Federal do Piaui - Universidade Federal do Piaui
🇧🇷Teresina, Brazil
Clinica de la Mujer
🇨🇴Bogota, Colombia
Opca bolnica Zadar
🇭🇷Zadar, Croatia
Centre Hospitalier Lyon Sud
🇫🇷Pierre-Bénite, France
CHU Saint-etienne
🇫🇷Saint Etienne, France
Medizinische Hochschule Hannover
🇩🇪Hannover, Germany
Gastroenterologische Spezialpraxis - Berlin-Karlshorst
🇩🇪Berlin-Karlshorst, Germany
Universitaetsklinikum Heidelberg
🇩🇪Heidelberg, Germany
Synexus Clinical Research GmbH
🇩🇪Frankfurt, Germany
Rabin Med Ctr Beilinson Hosp
🇮🇱Petah Tikva, Israel
Chaim Sheba Medical Center
🇮🇱Ramat Gan, Israel
AOU Policlinico G.Martino
🇮🇹Messina, Italy
Gruppo Ospedaliero San Donato - Istituto di Ricovero e Cura
🇮🇹Milano, Italy
IRCCS Humanitas Rozzano-IBD Center Malattie Infiammatorie Croniche Intestinali
🇮🇹Rozzano, Italy
Policlinico G.B.Rossi
🇮🇹Verona, Italy
Complesso Integrato Columbus
🇮🇹Rome, Italy
Chiba University Hospital
🇯🇵Chiba, Japan
Asahikawa City Hospital
🇯🇵Asahikawa, Japan
Nagoya University Hospital
🇯🇵Nagoya, Japan
Kagawa Prefectural Central Hospital
🇯🇵Takamatsu, Japan
Wakayama Medical University Hospital
🇯🇵Wakayama, Japan
The Catholic Univ. of Korea, DaeJeon St. Mary's Hospital
🇰🇷Seongnam, Korea, Republic of
Christchurch Hospital
🇳🇿Christchurch, New Zealand
ETG Zamosc
🇵🇱Zamosc, Poland
Hosp Reina Sofia
🇪🇸Córdoba, Spain
GBOU VPO Rostov State Medical University
🇷🇺Rostov-na-Donu, Russian Federation
Medical University Reaviz
🇷🇺Samara, Russian Federation
Firat University Hospital
🇹🇷Elazig, Turkey
Barnsley District General Hospital
🇬🇧Barnsley, United Kingdom
Addenbrooke's Hospital
🇬🇧Cambridge, United Kingdom
Gastroenterology Clinic Of San Antonio P A
🇺🇸San Antonio, Texas, United States
Gastroenterology Research of America, LLC
🇺🇸San Antonio, Texas, United States
UT Health Science Center at San Antonio
🇺🇸San Antonio, Texas, United States
Institute of Clinical Cardiology, Ltd.
🇬🇪Tbilisi, Georgia
CHU Grenoble
🇫🇷Grenoble, France
Groupement Hospitalier Universitaire Ouest
🇫🇷Paris, France
Assaf Harofeh Medical Center
🇮🇱Tzrifin, Israel
The second Xiangya Hospital of Central South University
🇨🇳Changsha, China
Peking University Third Hospital
🇨🇳Beijing, China
ZhuJiang Hospital of Southern Medical University
🇨🇳Guangzhou, China
Sun Yat-sen University - The Sixth Affiliated Hospital Guangdong Gastrointestinal Hospital
🇨🇳Guangzhou, China
First Affiliated Hospital of Gannan Medical University
🇨🇳Ganzhou, China
The Second Affiliated Hospital of Zhejiang University
🇨🇳Hangzhou, China
Huai'an 1st Hospital
🇨🇳Huai'an, China
The First Affiliated Hospital of NanChang University
🇨🇳Nanchang, China
Shanghai Ninth Peoples Hospital
🇨🇳Shanghai, China
Huashan Hospital Fudan University
🇨🇳Shanghai, China
Peking University Shenzhen Hospital
🇨🇳Shenzhen, China
The first affiliated hospital of suzhou University
🇨🇳Suzhou, China
Wuxi People s Hospital
🇨🇳Wuxi, China
Zhongshan Hospital, Xiamen University
🇨🇳Xiamen, China
Yangzhou First People's Hospital
🇨🇳Yangzhou, China
Zhangzhou Municipal Hospital of Fujian Province
🇨🇳Zhangzhou, China
The Hospital of Hyogo College of Medicine
🇯🇵Nishinomiya, Japan
Health Science Research Center
🇺🇸Pratt, Kansas, United States
University of Rochester Medical Center
🇺🇸Rochester, New York, United States
BVL Clinical Research
🇺🇸Leawood, Kansas, United States
Cotton O'Neil Digestive Health Center
🇺🇸Topeka, Kansas, United States
Vanderbilt University Medical Center
🇺🇸Nashville, Tennessee, United States
Integris Baptist Office
🇺🇸Oklahoma City, Oklahoma, United States
Irbid Specialty Hospital
🇯🇴Irbid, Jordan
Hospital Raja Perempuan Zainab Ii
🇲🇾Kota Bahru, Malaysia
University Of California San Diego
🇺🇸La Jolla, California, United States
University of Arizona
🇺🇸Tucson, Arizona, United States
CHU Saint-Pierre
🇧🇪Bruxelles, Belgium
Hopital Erasme
🇧🇪Bruxelles, Belgium
University Clinical Centre of the Republic of Srpska
🇧🇦Banja Luka, Bosnia and Herzegovina
Clinical hospital Mostar
🇧🇦Mostar, Bosnia and Herzegovina
Akh Wien
🇦🇹Wien, Austria
Healthcare Institution,Minsk Scientific center for surgery,
🇧🇾Minsk, Belarus
Vitebsk Regional Clinical Hospital
🇧🇾Vitebsk, Belarus
CHwapi
🇧🇪Tournai, Belgium
Medplus Medicina Prepagada S.A.
🇨🇴Bogota, Colombia
Centro Médico Imbanaco
🇨🇴Cali, Colombia
AZ Klina
🇧🇪Brasschaat, Belgium
Az Groeninge
🇧🇪Kortrijk, Belgium
Weill Cornell Medical College
🇺🇸New York, New York, United States
Laiko General Hospital of Athens
🇬🇷Athens, Greece
BAPS Pramukhswami Hospital
🇮🇳Surat, India
Bnai Zion Medical Center
🇮🇱Haifa, Israel
Royal University Hospital
🇨🇦Saskatoon, Saskatchewan, Canada
Algemeen Ziekenhuis Delta
🇧🇪Roeselare, Belgium
University Hospital of Heraklion
🇬🇷Heraklion, Greece
NYU Langone Medical Center
🇺🇸New York, New York, United States
Universitaetsklinikum Salzburg Landeskrankenhaus
🇦🇹Salzburg, Austria
Republican Research Centre of Radiation Medicine and Human E
🇧🇾Gomel, Belarus
Clinical Center University of Sarajevo
🇧🇦Sarajevo, Bosnia and Herzegovina
Polyclinic Dr. Al-Tawil
🇧🇦Sarajevo, Bosnia and Herzegovina
Cantonal Hospital Zenica
🇧🇦Zenica, Bosnia and Herzegovina
Endocare Ltda.
🇨🇴Bogota, Colombia
LTD 'Aversi Clinic'
🇬🇪T'bilisi, Georgia
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Corporacion para Estudios en Salud Clinica CES - Gastroenterology
🇨🇴Medellin, Colombia
Synexus Magyarorszag Kft
🇭🇺Gyula, Hungary
Surat Institute of Digestive Sciences Hospitals
🇮🇳Surat, India
Meddica Centre Hungarian Defence Froces
🇭🇺Budapest, Hungary
TSMU The First University Clinic
🇬🇪Tbilisi, Georgia
LTD 'Georgia Archangel St. Michael Multiprofile Clinical Hospital'
🇬🇪Tbilisi, Georgia
LTD Helsicore
🇬🇪Tbilisi, Georgia
Fortis Hospital
🇮🇳Noida, India
Unity Hospital
🇮🇳Surat, India
Péterfy Sándor utcai Kórház
🇭🇺Budapest, Hungary
Shree Giriraj Multispeciality Hospital
🇮🇳Rajkot, India
Jordan University Hospital
🇯🇴Amman, Jordan
Bellevue Medical Center
🇱🇧Beirut, Lebanon
University Malaya Medical Centre
🇲🇾Kuala Lumpur, Malaysia
Hospital Tengku Ampuan Afzan
🇲🇾Kuantan, Malaysia
University Clinic of Gastroenterohepatology
🇲🇰Skopje, North Macedonia
Prywatna Praktyka Lekarska
🇵🇱Jelenia Góra, Poland
AmiCare Centrum Medyczne
🇵🇱Lodz, Poland
NZOZ Centrum Medyczne KERmed
🇵🇱Bydgoszcz, Poland
Centrum Medyczne Promed
🇵🇱Krakow, Poland
H-T Centrum Medyczne Endoterapia
🇵🇱Tychy, Poland
Futuremeds sp. z o.o.
🇵🇱Wroclaw, Poland
Przychodnia Vistamed
🇵🇱Wroclaw, Poland
Centro Hospitalar e Universitário de Coimbra, EPE
🇵🇹Coimbra, Portugal
GBUZ of Moscow Region City Clinical Hospital #3
🇷🇺Podolsk, Russian Federation
King Abdullah University Hospital
🇯🇴Irbid, Jordan
Mount Lebanon Hospital
🇱🇧Beirut, Lebanon
Nini Hospital
🇱🇧Tripoli, Lebanon
Hospital Sultanah Aminah
🇲🇾Johor Bahru, Malaysia
Synexus Polska Sp. z o.o. Oddzial w Katowicach
🇵🇱Katowice, Poland
Centrum Opieki Zdrowotnej Orkan-med Stec-Michalska sj
🇵🇱Ksawerów, Poland
1 Wojskowy Szpital Kliniczny z Poliklinika SPZOZ w Lublinie
🇵🇱Lublin, Poland
Solumed S.C.
🇵🇱Poznan, Poland
Endoskopia Sp z o.o.
🇵🇱Sopot, Poland
King Abdullah Medical City in Holy Capital
🇸🇦Makkah, Saudi Arabia
King Abdul Aziz Medical City for National Guard Health Affairs
🇸🇦Riyadh, Saudi Arabia
KNP Kyivska miska klinichna likarnia №18 vykonavchoho orhanu KMR (KMDA)
🇺🇦Kyiv, Ukraine
Ternopil municipal hospital #1
🇺🇦Ternopil, Ukraine
Hospital Raja Permaisuri Bainun
🇲🇾Ipoh, Malaysia
General City Hospital 8mi Septemvri
🇲🇰Skopje, North Macedonia
Centrum Medyczne Lukamed
🇵🇱Chojnice, Poland
Synexus Polska Sp. z o.o. Oddzial w Czestochowie
🇵🇱Czestochowa, Poland
Centrum Medyczne Plejady
🇵🇱Krakow, Poland
Synexus Polska Sp. z o.o.
🇵🇱Lodz, Poland
Gastromed Spotka Z Ograniczona Odpowiedzialnoscia Sp. K.
🇵🇱Lublin, Poland
Wojewodzki Szpital Specjalistyczny w Olsztynie
🇵🇱Olsztyn, Poland
Centrum Medyczne
🇵🇱Warszawa, Poland
Centrum Zdrowia Tuchow
🇵🇱Wierzchoslawice, Poland
Melita Medical Sp. z o.o.
🇵🇱Wroclaw, Poland
EuroMediCare Szpital Specjalistyczny z Przychodnia
🇵🇱Wroclaw, Poland
Novgorod Regional Clinical Hospital n.a. N.A. Semashko
🇷🇺Nizhny Novgorod, Russian Federation
The Limited Liability Company Research center Eco-safety
🇷🇺Saint-Petersburg, Russian Federation
Academisch Ziekenhuis Maastricht
🇳🇱Maastricht, Netherlands
Stichting Zuyderland Medisch Centrum
🇳🇱Sittard-Geleen, Netherlands
Malopolskie Centrum Kliniczne
🇵🇱Krakow, Poland
Oswiecimskie Centrum Badan Klinicznych
🇵🇱Oswiecim, Poland
Centrum Diagnostyczno - Lecznicze Barska sp. z o.o. Szpital Specjalistyczny Barska
🇵🇱Wloclawek, Poland
EMC Instytut Medyczny SA
🇵🇱Poznan, Poland
Niepubliczny Zaklad Opieki Zdrowotnej
🇵🇱Szczecin, Poland
NZOZ Vivamed Zespol Lekarzy Specjalistow
🇵🇱Warsaw, Poland
Centralny Szpital Kliniczny MSWiA w Warszawie
🇵🇱Warszawa, Poland
ARS MEDICA Rybak Maria, Rybak Zbigniew, s.c.
🇵🇱Wroclaw, Poland
Synexus Polska Sp z o o Oddzial we Wroclawiu
🇵🇱Wrocław, Poland
Hospital de Portimao-Centro Hospitalar do Barlavento Algarvio
🇵🇹Portimao, Portugal
KGBUZ 'Regional Clinical Hospital'
🇷🇺Krasnoyarsk, Russian Federation
City Clinical Hospital #12
🇷🇺Novosibirsk, Russian Federation
FSBI 'Scientific Research Institute of Clinical and Experimental Lymphology' of Siberian Branch
🇷🇺Novosibirsk, Russian Federation
City Hospital named after St. Martyr Elizabeth
🇷🇺Saint-Petersburg, Russian Federation
Special hospital for Internal diseases, Oncomed system
🇷🇸Belgrade, Serbia
General Hospital 'Djordje Joanovic'
🇷🇸Zrenjanin, Serbia
ENDOMED s.r.o
🇸🇰Kosice, Slovakia
Hosp. Sra. Da Oliveira - Guimaraes
🇵🇹Guimarães, Portugal
Clinical Diagnostic Center 'Ultramed'
🇷🇺Omsk, Russian Federation
NUZ 'Railway Clinical Hospital on Samara station of LLC 'Russian Railways'
🇷🇺Samara, Russian Federation
GUZ Novgorod Regional Clinical Hospital
🇷🇺Velikiy Novgorod, Russian Federation
Zvezdara University Medical Center
🇷🇸Belgrade, Serbia
City Clinical Hospital #31
🇷🇺St. Petersburg, Russian Federation
GASTRO I. s.r.o.
🇸🇰Presov, Slovakia
St.Petersburg State Medical University n.a.Pavlov
🇷🇺St Petersburg, Russian Federation
Hospital La Rabta
🇹🇳Tunis Jebbari, Tunisia
Hopital Habib Thameur
🇹🇳Tunis, Tunisia
Military Hospital of Instruction of Tunis
🇹🇳Tunis, Tunisia
Odeska oblasna klinichna likarnia
🇺🇦Odesa, Ukraine
Hopital Regional Mohamed Tahar El Maamouri
🇹🇳Nabul, Tunisia
Hopital Universitaire Sahloul
🇹🇳Sousse, Tunisia
Kyiv Regional Clinical Hospital
🇺🇦Kyiv, Ukraine
MNCE City Clinical Hospital No 2 named after prof O O Shalimov of the Kharkiv City Council
🇺🇦Kharkiv, Ukraine
KZ Khersonska Miska Klinichna Likarnia Im. Ye.Ie.Karabelesha
🇺🇦Kherson, Ukraine
LLC Treatment and Diagnostic Center Adonis Plus
🇺🇦Kyiv, Ukraine
Medical Research and Practice Center Medbud of the Public Joint Stock Holding Company Kyivmiskbud
🇺🇦Kyiv, Ukraine
Kyiv Railway Clinical Hospital #2 Of Branch 'Health Center' Of The Company 'Ukrainian Railway'
🇺🇦Kyiv, Ukraine
MNCE Zakarpatska Regional Clinical Hospital named after A Novak of Zakarpatska Regional Council
🇺🇦Uzhgorod, Ukraine
KU 6 miska klinichna likarnia ZMR
🇺🇦Zaporozhye, Ukraine
Hopital Rangueil
🇫🇷Toulouse, France
Nagoya City University Hospital
🇯🇵Nagoya, Japan
Okayama Saiseikai General Hospital
🇯🇵Okayama, Japan
Osaka University Hospital
🇯🇵Suita-shi, Japan
Yokohama City University Medical Center
🇯🇵Yokohama, Japan
CMIP - Centro Mineiro de Pesquisa Ltda
🇧🇷Juiz de Fora, Brazil
Hospital das Clinicas de Porto Alegre
🇧🇷Porto Alegre, Brazil
Complexo Hospitalar de Niteroi
🇧🇷Niterói, Brazil
Kaiser Hospta
🇧🇷São José Do Rio Preto, Brazil
CEMEC - Centro Multidisciplinar de Estudos Clínicos
🇧🇷Santo André, Brazil
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto - Hospital de Base
🇧🇷Sao Jose do Rio Preto, Brazil
Hemomed
🇧🇷Sao Paulo, Brazil
CPCLIN - Centro de Pesquisas Clínicas
🇧🇷São Paulo, Brazil
Mater Hospital Brisbane
🇦🇺South Brisbane, Australia
Syracuse VA Medical Center
🇺🇸Syracuse, New York, United States
Clinical Research of West Florida
🇺🇸Tampa, Florida, United States
GCP Clinical Research
🇺🇸Tampa, Florida, United States
Florida Hospital Tampa
🇺🇸Tampa, Florida, United States
Alliance Clinical Research
🇺🇸Tampa, Florida, United States
Gastroenterology Group Of Naples
🇺🇸Naples, Florida, United States
Memorial Health Care System
🇺🇸Chattanooga, Tennessee, United States
Hosp. Univ. La Paz
🇪🇸Madrid, Spain
Nanpuh Hospital
🇯🇵Kagoshima, Japan
The 1st affiliated hospital of Anhui Medical University
🇨🇳Hefei, China
CHRU de Lille Hopital Claude Huriez
🇫🇷Lille, France
Hopital Nord Marseille
🇫🇷Marseille, France
Om Research LLC
🇺🇸Lancaster, California, United States
United Gastroenterologists
🇺🇸Murrieta, California, United States
Peak Gastroenterology Associates
🇺🇸Colorado Springs, Colorado, United States
Auzmer Research
🇺🇸Lakeland, Florida, United States
Synexus Clinical Research US Inc
🇺🇸Anderson, South Carolina, United States
Gastroenterology Clinic of Acadiana
🇺🇸Lafayette, Louisiana, United States
Tandem Clinical Research
🇺🇸Marrero, Louisiana, United States
Digestive Health Specialists PC
🇺🇸Chelmsford, Massachusetts, United States
Clinical Research Institute of Michigan, LLC
🇺🇸Chesterfield, Michigan, United States
Clinical Trials of America
🇺🇸Mount Airy, North Carolina, United States
Southwoods Health
🇺🇸Poland, Ohio, United States
Caprock Gastro Research
🇺🇸Lubbock, Texas, United States
Center for Gastrointestinal Health
🇺🇸Petersburg, Virginia, United States
Washington Gastroenterology, PLLC
🇺🇸Tacoma, Washington, United States
Austin Hospital
🇦🇺Heidelberg, Australia
The Queen Elizabeth Hospital
🇦🇺Adelaide, Australia
UZ Gent
🇧🇪Gent, Belgium
Instituto do Aparelho Digestivo
🇧🇷Porto Alegre, Brazil
Health Sciences Centre
🇨🇦Winnipeg, Manitoba, Canada
Barrie GI Associates
🇨🇦Barrie, Ontario, Canada
London Health Sciences Centre
🇨🇦London, Ontario, Canada
Pharmaceutical Integrated Research Company
🇨🇦Waterloo, Ontario, Canada
Universitatsklinikum Schleswig Holstein Kiel
🇩🇪Kiel, Germany
Peking University First Hospital
🇨🇳Beijing, China
Beijing Friendship Hospital
🇨🇳Beijing, China
Changzhou No 2 Peoples Hospital
🇨🇳Changzhou City, China
West China Hospital Sichuan University
🇨🇳Chengdu, China
The Military General Hospital of Beijing PLA
🇨🇳Beijing, China
The Second Affiliated Hospital of Chongqing Medical University
🇨🇳Chongqing, China
The First Affiliated Hospital Sun Yat-Sen University
🇨🇳Guangzhou, China
Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University
🇨🇳Guangzhou, China
Universitatsklinikum Ulm
🇩🇪Ulm, Germany
Sir Run Run Shaw Hospital, Zhejiang University School of Medicine
🇨🇳Hangzhou, China
Second Military Medical University (SMMU)
🇨🇳Shanghai, China
Shengjing Hospital Of China Medical University
🇨🇳Shenyang, China
Tongji Hospital of Tongji University
🇨🇳Shanghai, China
Ruijin Hospital Shanghai Jiao Tong University
🇨🇳Shanghai, China
The First Affiliated Hospital of Wenzhou Medical University
🇨🇳Wenzhou, China
Wuhan Union Hospital
🇨🇳Wuhan, China
Renmin Hospital of Wuhan University
🇨🇳Wuhan, China
Opca bolnica Bjelovar
🇭🇷Bjelovar, Croatia
Poliklinika Solmed
🇭🇷Zagreb, Croatia
CH Sestre Milosrdnice
🇭🇷Zagreb, Croatia
Fakultni nemocnice Kralovske Vinohrady
🇨🇿Praha 10, Czechia
University Hospital Center Zagreb
🇭🇷Zagreb, Croatia
University Hospital Dubrava
🇭🇷Zagreb, Croatia
NH Hospital, a.s.
🇨🇿Horovice, Czechia
Nemocnice Ceske Budejovice
🇨🇿Ceske Budejovice, Czechia
Synexus Czech s.r.o.
🇨🇿Prague 2, Czechia
CHU Amiens
🇫🇷Amiens, France
CHRU Besancon Hopital Jean Minjoz
🇫🇷Besançon, France
Centre Hospitalier Universitaire (CHU) de Caen
🇫🇷Caen, France
CHRU de Tours - Hopital Trousseau
🇫🇷Chambray Les Tours Centre, France
Centre Hospitalier Universitaire(CHU) - Hopital Henri Mondor
🇫🇷Créteil, France
CHU de Nantes hotel Dieu
🇫🇷Nantes, France
CHRU Montpellier - Hopital Saint-Eloi
🇫🇷Montpellier Cedex 5, France
CHU de Nice Hopital de l Archet
🇫🇷Nice cedex 03, France
CHU Nimes Hopital Caremeau
🇫🇷Nimes, France
Hôpital Bichat
🇫🇷Paris, France
Centre Hospitalier Universitaire de Reims, Hôpital Robert Debré
🇫🇷Reims, Cedex, France
Hopital D'Instruction Des Armees
🇫🇷Saint Mandé, France
CHU Toulouse - Hopital de Rangueil
🇫🇷Toulouse, France
CHU de Nancy_ Hopital Brabois
🇫🇷Vandoeuvre-les-Nancy, France
CHRU de Strasbourg - Hopital de Hautepierre
🇫🇷Strasbourg Cedex, France
LTD Unimed Kakheti- Telavi Referral Hospital
🇬🇪Telavi, Georgia
Klinikum Augsburg
🇩🇪Augsburg, Germany
Synexus Berlin Research Center
🇩🇪Berlin, Germany
Charite - Campus Mitte
🇩🇪Berlin, Germany
Klinikum Dresden
🇩🇪Dresden, Germany
Universitaetsklinikum Charite, Campus Virchow Klinikum
🇩🇪Berlin, Germany
Krankenhaus Waldfriede Mitte
🇩🇪Berlin, Germany
Agaplesion Frankfurter Diakonie Kliniken GmbH, Markus Krankenhaus
🇩🇪Frankfurt/Main, Germany
JWG-University Hospital
🇩🇪Frankfurt, Germany
Martini-Klinik am Universitätsklinikum Hamburg-Eppendorf Urologie
🇩🇪Hamburg, Germany
Asklepios Westklinikum
🇩🇪Hamburg, Germany
Staedtisches Klinikum Lueneburg
🇩🇪Lueneburg, Germany
Eugastro GmbH
🇩🇪Leipzig, Germany
Gastroenterologie und Hepatologie am Johannisplatz
🇩🇪Leipzig, Germany
Universitaetsklinikum Mannheim
🇩🇪Mannheim, Germany
Gemeinschaftspraxis Germania-Campus
🇩🇪Münster, Germany
Praxiszentrum Alte Mälzerei
🇩🇪Regensburg, Germany
Zentrum für Gastroenterologie Saar MVZ GmbH
🇩🇪Saarbrücken, Germany
Semmelweis Egyetem
🇭🇺Budapest, Hungary
Réthy Pál Kórház - Rendelőintézet
🇭🇺Békéscsaba, Hungary
Tolna Megyei Balassa Janos Korhaz
🇭🇺Szekszárd, Hungary
Apex Hospitals Ltd
🇮🇳Jaipur, India
Nirmal Hospital Pvt. Ltd.
🇮🇳Surat, India
Soroka Medical Center
🇮🇱Bear Sheva, Israel
Ha'Emek Medical Center
🇮🇱Afula, Israel
Barzilai Medical Center
🇮🇱Ashkelon, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Meir Medical Center
🇮🇱Kfar Saba, Israel
Hadassah Hebrew University Medical Center
🇮🇱Jerusalem, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Azienda Ospedaliero Universitaria di Cagliari - Policlinico Duilio Casula di Monserrato
🇮🇹Cagliari, Italy
Policlinico S.Orsola Malpighi, AOU di Bologna
🇮🇹Bologna, Italy
Ospedale Santissima Annunziata
🇮🇹Cento, Italy
Universita degli Studi di Padova - Azienda Ospedaliera di Padova
🇮🇹Padova, Italy
Università Campus Biomedico di Roma
🇮🇹Roma, Italy
Policlinico Universitario Agostino Gemelli
🇮🇹Roma, Italy
Casa Sollievo della Sofferenza
🇮🇹San Giovanni Rotondo, Italy
S.C. Gastroenterologia
🇮🇹Torino, Italy
Azienda Ospedaliero Universitaria S.Maria Della Misericordia
🇮🇹Udine, Italy
Tsujinaka Hospital Kashiwanoha
🇯🇵Kashiwa, Japan
Juntendo University Hospital
🇯🇵Bunkyo-ku, Japan
Fukuoka University Chikushi Hospital
🇯🇵Chikushino, Japan
Saiseikai Fukuoka General Hospital
🇯🇵Fukuoka-shi, Japan
Gifu University Hospital
🇯🇵Gifu, Japan
Fukuoka University Hospital
🇯🇵Fukuoka-shi, Japan
Tokai University Hachioji Hospital
🇯🇵Hachioji, Japan
Mito Medical Center - Digestive Organs
🇯🇵Higashiibaraki-gun, Japan
Matsuda Hospital
🇯🇵Hamamatsu-shi, Japan
National Hospital Organization Hirosaki General Medical Center
🇯🇵Hirosaki, Japan
Izumiotsu Municipal Hospital
🇯🇵Izumiotsu, Japan
Kagoshima IBD Gastroenterology Clinic
🇯🇵Kagoshima, Japan
Shimane University Hospital
🇯🇵Izumo, Japan
Hiroshima University Hospital
🇯🇵Hiroshima, Japan
Sameshima Hospital
🇯🇵Kagoshima, Japan
Aoyama Naika Clinic
🇯🇵Kobe, Japan
Kanazawa University Hospital
🇯🇵Kanazawa, Japan
Nara Medical University Hospital
🇯🇵Kashihara, Japan
Kobe University Hospital
🇯🇵Kobe, Japan
The Jikei University Hospital
🇯🇵Tokyo, Japan
National Hospital Organization Kochi National Hospital
🇯🇵Kochi, Japan
Yamanashi Prefectural Central Hospital
🇯🇵Kofu, Japan
Kurume University Hospital
🇯🇵Kurume, Japan
National Hospital Organization Kure Medical Center and Chugoku Cancer Center
🇯🇵Kure, Japan
University Hospital Kyoto Prefectural University of Medicine
🇯🇵Kyoto, Japan
Kyoto University Hospital
🇯🇵Kyoto, Japan
Kitasato University Kitasato Institute Hospital
🇯🇵Minato-ku, Japan
JRC Kyoto Daiichi Hospital
🇯🇵Kyoto, Japan
Osaki Citizen Hospital
🇯🇵Osaki, Japan
Iwate Medical University Hospital
🇯🇵Morioka, Japan
Kyorin University Hospital
🇯🇵Mitaka, Japan
National Hospital Organization Kyoto Medical Center
🇯🇵Kyoto, Japan
Aichi Medical University Hospital
🇯🇵Nagakute, Japan
Nagasaki University Hospital
🇯🇵Nagasaki, Japan
JA Obihiro Kosei Hospital
🇯🇵Obihiro, Japan
Nagaoka Red Cross Hospital
🇯🇵Nagaoka, Japan
Oita Red Cross Hospital
🇯🇵Oita, Japan
Kindai University Hospital
🇯🇵Osaka-Sayama, Japan
National Hospital Organization Osaka National Hospital
🇯🇵Osaka-shi, Japan
Nakagami Hospital
🇯🇵Okinawa, Japan
Kinshukai Infusion Clinic
🇯🇵Osaka, Japan
Kitano Hospital
🇯🇵Osaka, Japan
Japanese Red Cross Osaka Hospital
🇯🇵Osaka, Japan
Osaka City University Hospital
🇯🇵Osaka, Japan
National Hospital Organization Higashi Ohmi General Medical Center
🇯🇵Otsu-shi, Japan
Japan Community Health Care Organization Saitama Medical Center
🇯🇵Saitama, Japan
Shiga University of Medical Science Hospital
🇯🇵Otsu, Japan
Tokitokai Tokito Clinic Coloproctology Center
🇯🇵Saitama, Japan
Saitama Medical University Hospital
🇯🇵Saitama, Japan
Toho University Sakura Medical Center
🇯🇵Sakura, Japan
Sapporo IBD Clinic
🇯🇵Sapporo Chuo-ku, Japan
Hokkaido University Hospital
🇯🇵Sapporo-shi, Japan
Keio University Hospital
🇯🇵Shinjuku-ku, Japan
Tokyo Yamate Medical Center
🇯🇵Shinjuku-ku, Japan
Takamatsu Red Cross Hospital
🇯🇵Takamatsu, Japan
JA Sapporo-Kosei General Hospital - 1st Digestive Organs
🇯🇵Sapporo, Japan
Sapporo Higashi Tokushukai Hospital
🇯🇵Sapporo, Japan
Tokushima University Hospital
🇯🇵Tokushima, Japan
Ehime University Hospital
🇯🇵Toon, Japan
Toyama City Hospital
🇯🇵Toyama-shi, Japan
Mie University Hospital
🇯🇵Tsu, Japan
Fujita Health University Hospital
🇯🇵Toyoake, Japan
Khalidi Hospital and Medical Center
🇯🇴Amman, Jordan
Korea University Ansan Hospital
🇰🇷Ansan-si, Korea, Republic of
Inje University Haeundae Paik Hospital
🇰🇷Busan, Korea, Republic of
Kyongpook national university Medical center
🇰🇷Daegu, Korea, Republic of
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Kyungpook National University Hospital
🇰🇷Daegu, Korea, Republic of
The Catholic university of Korea, St. Vincent's Hospital
🇰🇷Gyeonggi-do, Korea, Republic of
Hallym University Dongtan Sacred Heart Hospital
🇰🇷Hwaseong-si, Korea, Republic of
Seoul National University Bundang Hospital
🇰🇷Seongnam-si, Korea, Republic of
Hotel Dieu de France Hospital
🇱🇧Beirut, Lebanon
CHA Bundang Medical Center, CHA University
🇰🇷Seongnam, Korea, Republic of
Kangbuk Samsung Hospital
🇰🇷Seoul, Korea, Republic of
Yonsei University College of Medicine
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Gangnam Severance Hospital
🇰🇷Seoul, Korea, Republic of
Ewha Womans University Mokdong Hospital
🇰🇷YangCheon-Gu, Korea, Republic of
Alda Pukisa arsta prakse
🇱🇻Riga, Latvia
Wonju Christian Hospital
🇰🇷Wonju, Korea, Republic of
Ain Wazein Hospital
🇱🇧Ain Wazein, Lebanon
Pauls Stradins Clinical University Hospital
🇱🇻Riga, Latvia
American Universitty of Beirut Medical Center
🇱🇧Beirut, Lebanon
St Georges Hospital university medical centre
🇱🇧Beirut, Lebanon
Rafik Hariri University Hospital
🇱🇧Beirut, Lebanon
Lietuvos sveikatos mokslų universiteto ligoninė Kauno klinik
🇱🇹Kaunas, Lithuania
Vilnius University Hospital Santaros Klinikos, Public Institution
🇱🇹Vilnius, Lithuania
Hospital Ampang
🇲🇾Ampang, Malaysia
Amsterdam UMC locatie VUMC
🇳🇱Amsterdam, Netherlands
Auckland City Hospital
🇳🇿Auckland, New Zealand
Waikato Hospital
🇳🇿Hamilton, New Zealand
Dunedin Hospital
🇳🇿Dunedin, New Zealand
Synexus Scm Sp. Z o.o. Oddzial Gdynia
🇵🇱Gdynia, Poland
Synexus Polska Sp. z o.o. Oddzial w Gdansku
🇵🇱Gdansk, Poland
Twoja Przychodnia
🇵🇱Poznan, Poland
Synexus Polska Sp. z.o.o. Oddzial w Poznaniu
🇵🇱Poznan, Poland
Centrum Medyczne 'Medyk' Sp. z o.o. K.
🇵🇱Rzeszow, Poland
Kiepury Clinic
🇵🇱Sosnowiec, Poland
Wojskowy Instytut Medyczny
🇵🇱Warszawa, Poland
Twoja Przychodnia - Szczecinskie Centrum Medyczne
🇵🇱Szczecin, Poland
GASTROMED, Specjalistyczne Centrum Gastrologii i Endoskopii, Specjalistyczne Gabinety Lekarskie
🇵🇱Torun, Poland
Centrum Badawcze Wspolczesnej Terapii
🇵🇱Warszawa, Poland
Szpital Pomnik Centrum Zdrowia Dziecka
🇵🇱Warszawa, Poland
Synexus Polska Sp z o o Oddzial w Warszawie
🇵🇱Warszawa, Poland
Hospital de Braga
🇵🇹Braga, Portugal
H. Santo António - Centro Hospitalar do Porto
🇵🇹Porto, Portugal
Centro Hospitalar de Entre o Douro e Vouga, E.P.E
🇵🇹Santa Maria da Feira, Portugal
Kazan State Medical University
🇷🇺Kazan, Russian Federation
San Juan Bautista School of Medicine
🇵🇷Caguas, Puerto Rico
State Scientific Centre of Coloproctology
🇷🇺Moscow, Russian Federation
City Hospital #20
🇷🇺Rostov-on-Don, Russian Federation
Clinical Hospital #122 n.a. after L.G. Sokolov
🇷🇺Saint Petersburg, Russian Federation
Saratov City Hospital #5
🇷🇺Saratov, Russian Federation
Tomsk Regional Clinical Hospital
🇷🇺Tomsk, Russian Federation
Ulyanovsk Regional Clinical Hospital
🇷🇺Ulyanovsk, Russian Federation
University Clinical Center of Serbia
🇷🇸Belgrade, Serbia
Clinical Hospital Center Bezanijska Kosa
🇷🇸Belgrade, Serbia
University Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
FNsP F.D.R. Banska Bystrica
🇸🇰Banska Bystrica, Slovakia
Hosp. Univ. Dr. Josep Trueta
🇪🇸Girona, Spain
Complejo Hosp Univ. de Ferrol
🇪🇸Ferrol, Spain
Hosp. Gral. Juan Ramon Jimenez
🇪🇸Huelva, Spain
Hosp. Virgen Del Rocio
🇪🇸Sevilla, Spain
Hosp. Provincial de Pontevedra
🇪🇸Pontevedra, Spain
Hosp. Univ. Central de Asturias
🇪🇸Oviedo, Spain
China Medical University Hospital
🇨🇳Taichung, Taiwan
Hosp. Alvaro Cunqueiro
🇪🇸Vigo, Spain
Hosp. Univ. de Torrejon
🇪🇸Torrejón de Ardoz, Spain
Chang-Hua Christian Hospital
🇨🇳Changhua, Taiwan
Hosp. Univ. Miguel Servet
🇪🇸Zaragoza, Spain
National Taiwan University Hospital
🇨🇳Taipei, Taiwan
Chang-Gung Memorial Hospital-Linkou
🇨🇳Taoyuan, Taiwan
Hacettepe University Medical Faculty
🇹🇷Ankara, Turkey
Mustafa Kemal University Research and Practise Hospital
🇹🇷Hatay, Turkey
Gulhane Egitim ve Arastirma Hastanesi
🇹🇷Ankara, Turkey
Acibadem Fulya Hospital
🇹🇷Istanbul, Turkey
BAU Medical Park Goztepe Hospital
🇹🇷Istanbul, Turkey
Sisli Etfal Egitim ve Arastirma Hospital
🇹🇷Istanbul, Turkey
Marmara University Medical Faculty
🇹🇷Istanbul, Turkey
Dokuz Eylul University Medical Faculty
🇹🇷Izmir, Turkey
SE 'National institute therapy named L.T. Maloi NAMS of Ukraine'
🇺🇦Kharkiv, Ukraine
St George's Healthcare NHS Trust
🇬🇧London, United Kingdom
Health Clinic Limited Liability Company
🇺🇦Vinnytsia, Ukraine
InvesClinic, LLC
🇺🇸Fort Lauderdale, Florida, United States
Chung-Ang University Hospital
🇰🇷Seoul, Korea, Republic of
Advanced Research Center Inc
🇺🇸Anaheim, California, United States
UC Davis Medical Center
🇺🇸Sacramento, California, United States
Omega Research Consultants
🇺🇸Orlando, Florida, United States
Care Access Research, Orlando
🇺🇸Orlando, Florida, United States
Florida Hospital
🇺🇸Orlando, Florida, United States
University North Carolina at Chapel Hill
🇺🇸Chapel Hill, North Carolina, United States
PMG Research of Winston-Salem
🇺🇸Winston-Salem, North Carolina, United States
Ochsner Clinic Foundation
🇺🇸New Orleans, Louisiana, United States
DelRicht Research
🇺🇸New Orleans, Louisiana, United States
Gastroenterology and Internal Medicine Research Institute (GIRI)
🇨🇦Edmonton, Alberta, Canada
University of Alberta- Ziedler Ledcor Centre
🇨🇦Edmonton, Alberta, Canada
University of Calgary
🇨🇦Calgary, Alberta, Canada
Royal Melbourne Hospital
🇦🇺Parkville, Australia
Royal Adelaide Hospital
🇦🇺North Terrace, Australia
Sir Charles Gairdner Hospital
🇦🇺Nedlands, Australia
Nanjing Drum Tower Hospital
🇨🇳Nanjing, China
Zhongda Hospital Southeast University
🇨🇳Nanjing, China
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto Hospital de Base
🇧🇷Sao Jose do Rio Preto, Brazil
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