Standard Follow-up Program (SFP) for Neuro-oncology Cancer Patients Treated With Radiotherapy
Trial Snapshot
- Phase
- Not Applicable
- Status
- Recruiting
- Enrollment
- 10,000
- Locations
- 1
- Primary Endpoint
- Radionecrosis
Study Overview
Brief Summary
Standardised evaluation of baseline data regarding tumor-, patient- and treatment-characteristics as well as follow-up data regarding tumor- and clinical-outcome of neuro-oncology patients treated with radical/curative radiotherapy.
Motive:
Currently there is limited data on dose-effect relationships of tissues and structures in and around the brain. This lack of knowledge hampers patient selection for proton therapy, technique innovations, and accurate prediction of treatment outcome.
Goal:
To evaluate the selection for radiation treatment, obtain more knowledge on dose-effect relationships and enable insight in necessary treatment technique innovations that would improve treatment outcome.
Study Design
- Study Type
- Observational
- Observational Model
- Cohort
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Patient with neuro-oncological cancer
- •Patient receiving a radiotherapy dose XXX Gy
Exclusion Criteria
- •Failure to comply with any of the inclusion criteria
Outcomes
Primary Outcomes
Radionecrosis
Time Frame: Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy.
Treatment associated radionecrosos measured with CTCAE
Treatment associated CNS toxicity
Time Frame: Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy.
Treatment associated CNS Toxicity
Secondary Outcomes
- Progression free survival(Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy)
- Treatment associated non-CNS toxicity(Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy)
- Overall survival(Before start of radiation therapy, at 2,5 years; 5 years 7,5 years, 10 years and 12,5 years after completion of radiation therapy.)