IT-DIAB (Therapeutic Innovation in Type 2 Diabetes) : Prospective Follow-up of a Cohort of Patients With Pre-diabetes Over 10 Years
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Pre-diabetes
- Sponsor
- Nantes University Hospital
- Enrollment
- 366
- Locations
- 1
- Primary Endpoint
- The main objective of the study is to understand the pathophysiological mechanisms involved in switching from pre-diabetes to type 2 diabetes and to identify new biomarkers of type 2 diabetes risk in this population
- Last Updated
- 8 years ago
Overview
Brief Summary
The main objective of the study is to follow prospectively a cohort of patients with pre-diabetes to understand the pathophysiological mechanisms involved in switching from pre-diabetes to type 2 diabetes and to identify new biomarkers of type 2 diabetes risk in this population.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adult patients (≥18 years)
- •Subjects with diabetes risk score ≥ 15
- •Subjects with impaired fasting glucose: blood glucose ≥ 1.10 g/l and \< 1 .26 g/L
- •Subjects affiliated with an appropriate social security system
Exclusion Criteria
- •Fasting glycemia ≥ 1.26 g/l
- •Fasting glycemia ≤ 1.10 g/l
- •Subjects previously treated with oral anti-diabetic: metformin, glitazones, inhibitors of α-glucosidase, sulfonylurea, repaglinide, inhibitors of DPP-IV, GLP-1 R agonists.
- •Subjects previously treated with insulin, except gestational diabetes
- •Severe coagulation disorders
- •Thrombocytopenia \< 100 000/mm 3
- •Severe psychiatric disorders
- •Severe renal insufficiency (creatinine clearance \< 30 ml/min)
- •Severe hepatic insufficiency (TP \< 50%)
- •Alcohol abuse (\> 30g/j)
Outcomes
Primary Outcomes
The main objective of the study is to understand the pathophysiological mechanisms involved in switching from pre-diabetes to type 2 diabetes and to identify new biomarkers of type 2 diabetes risk in this population
Time Frame: 10 years
The main objective of the study is to follow prospectively a cohort of patients with pre-diabetes to understand the pathophysiological mechanisms involved in switching from pre-diabetes to type 2 diabetes and to identify new biomarkers of type 2 diabetes risk in this population
Secondary Outcomes
- Relation between "working hours and conditions" and metabolic disease(10 years)
- Number of patients with high Diabetes Risk Score and pre-diabetes(10 years)
- Number of patients with others cardiovascular risk factors(10 years)
- HbA1c measurement(10 years)
- Number of patients with pre-diabetes(10 years)