Measurement of the Folate Receptor in Blood

Completed

• Conditions: Healthy

• Registration Number: NCT00838747
• Lead Sponsor: Royal Marsden NHS Foundation Trust

Brief Summary

The folate receptor (FR) is a cell marker that is over expressed on the cell surface of certain cancers, this occurs most frequently in ovarian cancers. Some normal tissues also express the FR, however in these normal tissues the FR is usually located on the tissue surface that is inaccessible to circulating drugs. As such, drugs which target the FR may potentially be used to achieve anti-tumour efficacy whilst reducing toxicity to normal tissues. Therefore the ability to measure FR levels from different cancer types may help to select patients who are most likely to benefit from treatment with FR targeted therapies. One such drug BGC 945 is currently being tested in preclinical study at The Institute of Cancer Research

Detailed Description

A method has been developed in the laboratory which has been able to measure FR obtained from cancer cells in culture that has been added into blood. We would like to study if this method can measure FR in plasma and serum obtained from patients with ovarian cancer. We would also like to analyse plasma and serum samples obtained from healthy volunteers to determine if they have any appreciable levels of FR, which can then be compared to the measurements obtained from cancer patients.

Study Timeline

• Study Start: 2008-09
• Study First Submitted: 2008-09-05
• Study First Submitted QC: 2009-02-05
• Study First Posted: 2009-02-06
• Primary Completion: 2011-01
• Study Completion: 2011-07
• Status Verified: 2016-05
• Last Update Submitted: 2016-05-25
• Last Update Posted: 2016-05-26

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 7

Inclusion Criteria

• Patients with stage III/IV ovarian cancer
• healthy volunteers who are staff at the ICR and RMH

Exclusion Criteria

• patients or healthy volunteers who are unable to give informed consent
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To measure the levels of folate receptor in blood samples obtained from patients with ovarian cancer and from healthy volunteers	1 year

Trial Locations

Locations (1)

Royal Marsden NHS Foundation Trust; 🇬🇧 London, Sutton, United Kingdom