Effect of xylitol in treatment of post-orthodontic white spot lesions

Phase 3

Recruiting

Conditions: White spot lesions.
Dental caries on smooth surface limited to enamel
K02.61

Registration Number: IRCT20180913041032N2

Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: All

Target Recruitment: 84

Inclusion Criteria

The subjects will be chosen within patients aged between 14 and 25 years old who had completed fixed appliance orthodontic therapy recently.
Have at least one WSL on the facial surface of eight maxillary anterior teeth that was not presented before orthodontic treatment.

Exclusion Criteria

Patient’s unwillingness to be randomly assigned to one of the three treatment groups
Ongoing medication for a chronic disease
Chronic conditions such as asthma and allergy
Any abnormal oral, medical, mental condition or neuropsychiatric disorders
Regular use of oral antiseptics
Any WSLs present on qualifying teeth with frank cavitation,
Extensive restorations on the facial surfaces of the study teeth
Dental morphologic, anatomical or developmental anomalies
Alterations of the enamel, e.g. hypoplasia, fluorosis
Chronic use of medication causing a dry mouth or known xerostomia
Known pregnancy or breastfeeding during the course of the study
Professional administration or home use of highly concentrated fluoride products not related to the study during the whole study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Visual assessment of white spot lesions. Timepoint: Baseline and one year later. Method of measurement: The labial surfaces of the maxillary incisors, cuspids and premolars will be assessed according to Gorelick et al : Score 1 = no white spot formation; Score 2 = slight white spot formation (thin rim); Score 3 = excessive white spot formation (thicker bands); and Score 4 = white spot formation with cavitation.

Secondary Outcome Measures