Effect of Increasing The Dose of Nalbuphine As AN Adjuvant To Local Anesthetic In Paravertebral Block In Mastectomies.A Randomised Double Blinded Stud

Not Applicable

• Conditions: Cancer; Surgery; breast cancer surgeries mastectomies

• Registration Number: PACTR201711002797317
• Lead Sponsor: Fayoum University hospitals

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2017-11-23
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Pending
• Sex: Female
• Target Recruitment: 60

Inclusion Criteria

Sixty )60( patients American Society of Anesthesiologist (ASA) physical status I/II/III females, aged (18-78) years, undergoing breast surgery will be studied.

Exclusion Criteria

Exclusion criteria included patients undergoing bilateral breast surgery or breast reconstruction;
those having contra-indications for PVB, e.g., patient refusal,
infection at injection site, anticoagulant therapy,
abnormal coagulation profile,
or hypersensitivity to LA;
patients on chronic antiemetics or chronic pain medication;
pregnant patients;
central neuropathy,
liver or renal impairment,
drug or alcohol abusers,
and those with psychiatric illnesses that would interfere with perception and assessment of pain
and obese patients with a body mass index (BMI) >30 kg/m2.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome measure was cumulative IV tramadol consumption over 24 h, pain scores at rest and active movement of ipsilateral arm.

Secondary Outcome Measures

Name	Time	Method
Secondary outcome measures will include intraoperative fentanyl requirements, TFR, bradycardia , hypotension, sedation scores, complications ( nausea. vomiting, pruritus), time to mobilize, time to discharge and patient satisfaction.