NCT05378516UnknownNot Applicable
Placental Pathology and Inflammatory Factor Analysis of Obstetric Antiphospholipid Syndrome Patients
Peking University People's Hospital1 site in 1 country40 target enrollmentStarted: January 1, 2022Last updated:
Conditions
Trial Snapshot
- Phase
- Not Applicable
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- expression of ACC1 in placenta in pregnancy with/without antiphospholipid syndrome
Study Overview
Brief Summary
This investigation is on placental pathological changes and inflammatory factors associated with obstetric antiphospholipid syndrome.
Detailed Description
- To clarify the correlation between antiphospholipid antibody, ACC1 expression level, Treg cell and placental pathological changes associated with antiphospholipid syndrome. 2. Reveal that antiphospholipid antibodies affect Treg cell differentiation through the key enzyme of lipid metabolism ACC1.
Study Design
- Study Type
- Observational
- Observational Model
- Case Control
- Time Perspective
- Prospective
Eligibility Criteria
- Ages
- 18 Years to 50 Years (Adult)
- Sex
- Female
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •pregnant women with antiphospholipid syndrome (diagnosed by experts with clinical evidence) and healthy pregnant women without antiphospholipid syndrome as a control group
- •consent to join this study and finish the informed consents
Exclusion Criteria
- •pregnant women with other autoimmune diseases
Outcomes
Primary Outcomes
expression of ACC1 in placenta in pregnancy with/without antiphospholipid syndrome
Time Frame: in two years
Secondary Outcomes
No secondary outcomes reported
Investigators
Yang Jingjing
Deputy chief physician
Peking University People's Hospital
Study Sites (1)
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