Placental Pathology and Inflammatory Factor Analysis of OAPS

• Conditions: Antiphospholipid Syndrome in Pregnancy
• Interventions: Other: no intervention

• Registration Number: NCT05378516
• Lead Sponsor: Peking University People's Hospital

Brief Summary

This investigation is on placental pathological changes and inflammatory factors associated with obstetric antiphospholipid syndrome.

Detailed Description

1. To clarify the correlation between antiphospholipid antibody, ACC1 expression level, Treg cell and placental pathological changes associated with antiphospholipid syndrome. 2. Reveal that antiphospholipid antibodies affect Treg cell differentiation through the key enzyme of lipid metabolism ACC1.

Study Timeline

• Status Verified: 2022-01
• Study Start: 2022-01-01
• Primary Completion: 2022-05-12
• Study First Submitted: 2022-05-12
• Study First Submitted QC: 2022-05-12
• Last Update Submitted: 2022-05-12
• Study First Posted: 2022-05-18
• Last Update Posted: 2022-05-18
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: Female
• Target Recruitment: 40

Inclusion Criteria

1. pregnant women with antiphospholipid syndrome (diagnosed by experts with clinical evidence) and healthy pregnant women without antiphospholipid syndrome as a control group
2. consent to join this study and finish the informed consents

Exclusion Criteria

pregnant women with other autoimmune diseases

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
obstetric antiphospholipid syndrome	no intervention	obstetric antiphospholipid syndrome 20 cases and normal pregnant women 20 cases

Primary Outcome Measures

Name	Time	Method
expression of ACC1 in placenta in pregnancy with/without antiphospholipid syndrome	in two years

Trial Locations

Locations (1)

PekingUPH; 🇨🇳 Pekin, China