The Impact of Placental Factors on Fetal Intrauterine Growth and in Intrauterine Programming of the Metabolic Syndrome
试验速览
- 阶段
- 不适用
- 入组人数
- 160
- 试验地点
- 1
- 主要终点
- Rate of Copy Number Variations
研究概览
简要总结
Genetic and environmental factors are believed to play a major role in intrauterine growth and intrauterine programming. We intend to study genetic factors such as Telomere homeostasis, senescence, genomic instability and the presence of Genomic copy number variations in placental tissue from pregnancies complicated with Intrauterine growth restriction(IUGR), Gestational and pre gestational Diabetes, placentas from IVF pregnancies and from normal pregnancies. We also intend to assess these factors in cord blood and maternal blood.
详细描述
Based on the previous data from our group as well as other laboratories, we postulate that there is a correlation between impaired telomere homeostasis, senescence genomic instability and intra-uterine programming in placentas and in fetuses exposed to suboptimal intrauterine conditions such as hypoxia or hyperglycemia. Improved understanding of the mechanisms that produce the genomic changes in IUGR placentas and their influence on later risks of developing the metabolic syndrome should provide basis for future research that might lead into improved outcome of IUGR fetuses.
研究设计
- 研究类型
- Observational
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •A diagnosis of Intrauterine growth restriction
- •A diagnosis of Gestational diabetes
- •A diagnosis of pre gestational Diabetes
- •IVF pregnancy
排除标准
- •chorioamnionitis
- •meconium stained amniotic fluid
- •A request of the patient for Cord blood retrieval for preservation
结局指标
主要结局
Rate of Copy Number Variations
时间窗: 10 yeras
次要结局
- Telomere length(10 years)
- Number of copies of mitochondrial DNA(10 years)