Interplay of miRNA-146a and miRNA-126 in Chronic Periodontitis Patients With Coronary Artery Disease

Completed

• Conditions: Coronary Artery Disease; miRNA; Chronic Periodontitis

• Registration Number: NCT04583085
• Lead Sponsor: Meenakshi Ammal Dental College and Hospital

Brief Summary

The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further. The investigators attempt to quantify and compare the levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples obtained from patients diagnosed with chronic periodontitis with and without coronary artery disease.

Detailed Description

The role of micro-RNAs in chronic periodontitis associated with CAD is still in an incipient stage needs to be explored further. The investigators attempt to quantify and compare the levels of micro-RNA 146a and micro-RNA 126 in subgingival as well as coronary plaque samples obtained from patients diagnosed with chronic periodontitis with and without coronary artery disease.

Seventy-five participants were selected and grouped into 3 categories; 25 patients diagnosed with chronic periodontitis and coronary artery disease: CP + CAD group; 25 patients diagnosed with chronic periodontitis alone: CP group; and 25 systemically and periodontally healthy controls (HP). Demographic variables, periodontal parameters, cardiac parameters, blood pressure were obtained. miRNA-146a and miRNA126 levels were assessed in subgingival plaque (SP) samples from all the three groups. Within CP+CAD group, SP samples of CP+CADa were compared with coronary plaques samples (CP) of CP+CADb while the patient underwent CABG.

Study Timeline

• Study Start: 2018-11-01
• Primary Completion: 2019-12-01
• Study Completion: 2019-12-31
• Status Verified: 2020-10
• Study First Submitted: 2020-10-03
• Study First Submitted QC: 2020-10-08
• Last Update Submitted: 2020-10-09
• Study First Posted: 2020-10-12
• Last Update Posted: 2020-10-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 75

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
micro-RNA 146-a expression in Chronic periodontitis patients with and without coronary heart disease.	10 months	microRNA 146-a expression was present in the chronic periodontitis subjects with coronary heart disease
Levels of micro-RNA 126 in chronic periodontitis patients with and without coronary heart disease	10 months	microRNA 126 expression was present in chronic periodontitis subjects with coronary heart disease

Trial Locations

Locations (1)

Meenakshi Ammal Dental college; 🇮🇳 Chennai, Tamil Nadu, India