Exploring the Role of Almonds in Enhancing Immune Strength
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 48
- 试验地点
- 2
- 主要终点
- change in Natural Killer Function
研究概览
简要总结
The COVID-19 pandemic highlights the importance of good nutritional status for immune strength and for reducing comorbidities that increase morbidity and mortality of infections. The major aim of this study is test if almond consumption can improve immune function.
详细描述
Investigators will conduct an 8-week parallel-arm trial of 48 overweight/non-obese (BMI=24-30) adult (aged 40-65 years) men (n=24) and women (n=24) who will be randomly assigned to consume daily isoenergetic portions of almonds or a common snack (pretzels).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Healthy male and female subjects aged 40-65 y
- •Body mass index (BMI) 24-30 kg/m.2
排除标准
- •Not willing to stop taking multivitamins, and supplements (with the exception of vitamin D and calcium), for 30 days prior to or during study participation, if currently taking these.
- •Almond allergies
- •Alcohol consumption >2 drinks per day.
- •Smoking or using nicotine containing products in the last 6 months.
结局指标
主要结局
change in Natural Killer Function
时间窗: Baseline, after 8 weeks
The ability of peripheral blood mononuclear cells to bind and kill leukemia cells will be measured at baseline and at week-8 of the diet intervention using flowcytometry by assessing the concentration of natural killer cells.
次要结局
- change in Cytokines(Baseline, after 8 weeks)
研究者
Mark Kern
Professor
San Diego State University