Analgesic effects of Ivabradine on inflammatory pain in healthy volunteers
Not Applicable
- Conditions
- healthy volunteers
- Registration Number
- JPRN-UMIN000023022
- Lead Sponsor
- Shinshu University
- Brief Summary
A total of 20 healthy subjects were enrolled in this study (10 ivabradine first, 10 placebo first). Primary outcome Ivabradine (a HCN channel blocker), orally administered three times in two days, did not affect capsaicin-induced spontaneous pain compared to placebo. Secondary outcomes Ivabradine did not affect heat pain threshold in the primary zone, area of flare, and area of secondary mechanical hyperalgesia. In contrast, ivabradine reduced area of secondary mechanical allodynia compared to placebo.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
chronic pain history of heart failure electrocardiogram abnormality pregnant female regular use of analgesics neurologic deficits psychotic and depressive disorder
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effects of Ivabradine on spontaneous pain produced by Capsaicin
- Secondary Outcome Measures
Name Time Method Effects of oral administration of Ivabradine on the thermal hyperalgesia, mechanical hyperalgesia, mechanical allodynia, and flare produced by topical application of Capsaicin