Cardiopulmonary Effects of Intrathoracic Pressure Overshoot During Carbon Dioxide Insufflation in Thoracoscopic Surgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 232
- 主要终点
- thoracic pressure overshoot
研究概览
简要总结
Video-assisted thoracoscopic surgery (VATS) has become a standard technique for addressing all types of thoracic pathology. Insufflation of carbon dioxide (CO2) into the operated chest cavity could increase lung collapse and improve surgical field view. The actual thoracic pressure values may not be identical with the presetting on the insufflator display. This overshoot pressure during VATS may compromise cardiac and pulmonary function. The purpose of this study is to evaluate the effects of intrathoracic pressure overshoot during two-lung ventilation on the hemodynamic and respiratory function and clarify the relative safety of two different techniques of insufflation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Care Provider, Outcomes Assessor)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •American Society of Anesthesiologists (ASA) Physical Status Ⅰ,Ⅱ
- •Patients with esophageal carcinoma
- •Elective video-assisted thoracic surgery
排除标准
- •Allergic to drugs used in the study
- •Refusal of VAST
- •Arrhythmia or treated with antiarrhythmic drug
- •Surgery type were converted to thoracotomy,
- •Massive intraoperative blood loss (> 400ml)
结局指标
主要结局
thoracic pressure overshoot
时间窗: one hour during CO2 insufflation
Time and value of thoracic pressure overshoot during CO2 insufflation
Hemodynamic change
时间窗: one hour during CO2 insufflation
Hemodynamic changes during each overshoot including Systolic Blood Pressure, Central Venous Pressure and Heart Rate
Respiratory change
时间窗: one hour during CO2 insufflation
Respiratory changes during each overshoot including Peak Inspiratory Pressure, Pressure flat, Arterial Oxygen Saturation and End-tidal Carbon dioxide
次要结局
未报告次要终点
研究者
Qingxiang Mao
M.D.
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University