The effect of drug dexmedetomidine nebulization on circulatory parameters due to laryngoscopy and intubation in patients during general anaesthesia

Not yet recruiting

Conditions: Other complications of anesthesia, (2) ICD-10 Condition: O||Medical and Surgical,

Registration Number: CTRI/2021/04/032855

Lead Sponsor: Government Medical College and Hospital Chandigarh

Brief Summary: Till date, numerous drugs and various routes have been tried to attenuate his stress response such as opioids, vasodilators, beta-blockers, calcium channel blockers, intravenous lignocaine, topical sprays, volatile agents, alpha 2 agonists but none of the agents proved to be ideal. Dexmedetomidine, a selective alpha 2 adrenoceptor agonist. is short acting and has sedative, hypnotic, anxiolytic, analgesic, anti-sialagogue, sympatholytic properties and promotes cardiac, respiratory and neurological stability. Itâ€™s pleiotropic effects have led to its increasing use in the perioperative period.

Dexmedetomidine has the potential to produce bradycardia and hypotension when administered as a bolus. In a way to overcome this problem, nebulization route was chosen. Moreover, nebulized dexmedetomidine has a bioavailability of 65% through the nasal mucosa and 82% through the buccal mucosa.. Nebulised drug administration may be preferred over intranasal administration, as it avoids transient nasal irritation, cough, vocal cord irritation or laryngospasm.

However, limited number of studies are available on the usefulness of the dexmedetomidine drug nebulization on the haemodynamic response to laryngoscopy and intubation. Thus, the primary aim of this study will be to evaluate the effect of preoperative dexmedetomidine nebulization on the heart rate and blood pressure response to laryngoscopy and intubation in adult patients. The secondary aim is to evaluate time to extubation and a 2 hour incidence of postoperative pain and sore throat.

Detailed Description: Not available

Recruitment & Eligibility

Status: Not Yet Recruiting

Sex: All

Target Recruitment: 104

Inclusion Criteria

American Society of Anaesthesiologist(ASA) physical status I and II.
Age group between 18 to 60 years.

Exclusion Criteria

Patients with anticipated difficult airway (Airway Difficulty Score>8).
Patients with a body mass index (BMI)>35kg/m2 3.
Patients with uncontrolled hypertension.
Patients with known allergy to study drug.
Pregnant patients.

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The primary aim will be to evaluate the effects on the heart rate and blood pressure response in adult patients.	The time points will be the baseline parameters, before nebulization, after nebulization, 1 min after intubation, 5 min after intubation, 10 min after intubation and 2 hrs postop

Secondary Outcome Measures

Name	Time	Method
The secondary aims will be to evaluate the postoperative pain and sore throat.	The secondary aims will be evaluated 2 hours postoperatively.

Trial Locations

Locations (1): Government Medical College and Hospital , Chandigarh
🇮🇳
Chandigarh, CHANDIGARH, India
Government Medical College and Hospital , Chandigarh
🇮🇳Chandigarh, CHANDIGARH, India
Dr Apurva Rathour
Principal investigator
6284916781
apurva.rt9@gmail.com