Sex hormones, cognition, and the role of cardiovascular and psychological factors: a study in elderly transgender women and men receiving long-term gender-affirming hormone therapy in comparison with cis men and women from the LASA cohort.

Completed

Conditions: patienten met genderdysforie
gender dysphoria
gender incongruence

Registration Number: NL-OMON50025

Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 120

Inclusion Criteria

Age >55 years
Diagnosis of gender dysphoria
Continued and consistent use of GHT for at least 10 years
Currently in treatment at the Center of Expertise on Gender Dysphoria (i.e.,
last clinical appointment <2 years ago)

Exclusion Criteria

No sufficient understanding of the Dutch language
Subjects that indicate on forehand to be too frail for full participation in
the study

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Endpoints that are of particular interest to this study and have been studied<br /><br>within the LASA framework include: general cognitive functioning (Mini-Mental<br /><br>State Examination), coding task, 15-word test (immediate and delayed recall),<br /><br>letter and category fluency, GIT, and number series (forward and backward). An<br /><br>exhaustive list of items that are part of the general LASA data collection can<br /><br>be found in Huisman et al (2011), and Hoogendijk et al. (2016), attached.</p><br>

Secondary Outcome Measures