A Clinical Trial of a New Combination Treatment, Domvanalimab and Zimberelimab, Plus Chemotherapy, for People With an Upper Gastrointestinal Tract Cancer That Cannot be Removed With Surgery That Has Spread to Other Parts of the Body
- Conditions
- Advanced Upper Gastrointestinal Tract Adenocarcinoma
- Interventions
- Registration Number
- NCT05568095
- Lead Sponsor
- Arcus Biosciences, Inc.
- Brief Summary
This randomized Phase 3 open-label study will compare the efficacy of the T-cell immunoglobulin and immunoreceptor tyrosine-based inhibitory motif (ITIM) domain (TIGIT) monoclonal antibody domvanalimab, the anti programmed cell death protein 1 (PD-1) monoclonal antibody zimberelimab, and multiagent chemotherapy versus the anti PD-1 monoclonal antibody nivolumab and multiagent chemotherapy in the first-line treatment of participants with locally advanced unresectable or metastatic gastric, gastroesophageal junction (GEJ), and esophageal adenocarcinoma.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ACTIVE_NOT_RECRUITING
- Sex
- All
- Target Recruitment
- 1040
- Capable of giving signed informed consent which is in compliance with the requirements and restrictions listed in the informed consent form (ICF) and in protocol.
- Histologically confirmed diagnosis of locally advanced unresectable or metastatic gastric, GEJ, or esophageal adenocarcinoma.
- Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
- At least one measurable target lesion per Response Evaluation Criteria in Solid Tumors (RECIST) v1.1.
Key
- Underlying medical or psychiatric conditions that, in the investigator's or sponsor's opinion, will make the administration of study-specified therapy hazardous, including but not limited to:
- Interstitial lung disease, including history of interstitial lung disease or non-infectious pneumonitis. Active viral, bacterial, or fungal infections requiring parenteral treatment within 14 days of randomization.
- Clinically significant cardiovascular disease, such as New York Heart Association Class II or greater cardiac disease or cerebrovascular accident within 3 months prior to randomization, unstable angina, or new onset angina within 3 months prior to randomization, myocardial infarction within 6 months prior to randomization, or unstable arrhythmia within 3 months prior to randomization.
- History of prior solid-organ transplantation, including allogenic bone marrow transplantation.
- Dementia, psychiatric, or substance abuse disorders that would interfere with satisfying the requirements of the trial.
- Known human epidermal growth factor receptor 2 (HER-2) positive tumor.
- Known untreated, symptomatic, or actively progressing central nervous system (CNS) (brain) metastases. Participants with leptomeningeal metastases are excluded from enrollment.
- Received prior systemic treatment for locally advanced unresectable or metastatic gastric, GEJ, or esophageal adenocarcinoma.
- Disease progression within 6 months of completion of neoadjuvant or adjuvant therapy.
Note: Other protocol defined Inclusion/Exclusion criteria may apply.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Domvanalimab + Zimberelimab + FOLFOX/CAPOX (PI Choice) Domvanalimab Participants in this arm will receive Domvanalimab and zimberelimab doses once every 4 weeks (Q4W) in addition to chemotherapy with FOLFOX (oxaliplatin, leucovorin, fluorouracil) once every 2 weeks (Q2W) or Domvanalimab and zimberelimab once every 3 weeks (Q3W) in addition to chemotherapy with CAPOX (capecitabine and oxaliplatin) Q3W. Nivolumab + FOLFOX/CAPOX (PI Choice) Fluorouracil Participants in this arm will receive Nivolumab Q2W and FOLFOX Q2W or Nivolumab Q3W + CAPOX Q3W. Domvanalimab + Zimberelimab + FOLFOX/CAPOX (PI Choice) Oxaliplatin Participants in this arm will receive Domvanalimab and zimberelimab doses once every 4 weeks (Q4W) in addition to chemotherapy with FOLFOX (oxaliplatin, leucovorin, fluorouracil) once every 2 weeks (Q2W) or Domvanalimab and zimberelimab once every 3 weeks (Q3W) in addition to chemotherapy with CAPOX (capecitabine and oxaliplatin) Q3W. Domvanalimab + Zimberelimab + FOLFOX/CAPOX (PI Choice) Zimberelimab Participants in this arm will receive Domvanalimab and zimberelimab doses once every 4 weeks (Q4W) in addition to chemotherapy with FOLFOX (oxaliplatin, leucovorin, fluorouracil) once every 2 weeks (Q2W) or Domvanalimab and zimberelimab once every 3 weeks (Q3W) in addition to chemotherapy with CAPOX (capecitabine and oxaliplatin) Q3W. Domvanalimab + Zimberelimab + FOLFOX/CAPOX (PI Choice) Capecitabine Participants in this arm will receive Domvanalimab and zimberelimab doses once every 4 weeks (Q4W) in addition to chemotherapy with FOLFOX (oxaliplatin, leucovorin, fluorouracil) once every 2 weeks (Q2W) or Domvanalimab and zimberelimab once every 3 weeks (Q3W) in addition to chemotherapy with CAPOX (capecitabine and oxaliplatin) Q3W. Domvanalimab + Zimberelimab + FOLFOX/CAPOX (PI Choice) Fluorouracil Participants in this arm will receive Domvanalimab and zimberelimab doses once every 4 weeks (Q4W) in addition to chemotherapy with FOLFOX (oxaliplatin, leucovorin, fluorouracil) once every 2 weeks (Q2W) or Domvanalimab and zimberelimab once every 3 weeks (Q3W) in addition to chemotherapy with CAPOX (capecitabine and oxaliplatin) Q3W. Domvanalimab + Zimberelimab + FOLFOX/CAPOX (PI Choice) Leucovorin Participants in this arm will receive Domvanalimab and zimberelimab doses once every 4 weeks (Q4W) in addition to chemotherapy with FOLFOX (oxaliplatin, leucovorin, fluorouracil) once every 2 weeks (Q2W) or Domvanalimab and zimberelimab once every 3 weeks (Q3W) in addition to chemotherapy with CAPOX (capecitabine and oxaliplatin) Q3W. Nivolumab + FOLFOX/CAPOX (PI Choice) Capecitabine Participants in this arm will receive Nivolumab Q2W and FOLFOX Q2W or Nivolumab Q3W + CAPOX Q3W. Nivolumab + FOLFOX/CAPOX (PI Choice) Leucovorin Participants in this arm will receive Nivolumab Q2W and FOLFOX Q2W or Nivolumab Q3W + CAPOX Q3W. Nivolumab + FOLFOX/CAPOX (PI Choice) Oxaliplatin Participants in this arm will receive Nivolumab Q2W and FOLFOX Q2W or Nivolumab Q3W + CAPOX Q3W. Nivolumab + FOLFOX/CAPOX (PI Choice) Nivolumab Participants in this arm will receive Nivolumab Q2W and FOLFOX Q2W or Nivolumab Q3W + CAPOX Q3W.
- Primary Outcome Measures
Name Time Method Overall survival From randomization until death from any cause (Approximately 15 months)
- Secondary Outcome Measures
Name Time Method Progression-free survival (PFS) Approximately 15 months Objective response rate (ORR) Approximately 15 months Duration of response (DOR) Approximately 15 months Incidence and severity of adverse events (AEs) and serious adverse events (SAEs) Approximately 15 months Time to first symptom deterioration in the FACT-Ga gastric cancer subscale. Approximately 15 months
Trial Locations
- Locations (202)
UCLA Ronald Reagan Med Ctr
🇺🇸Santa Monica, California, United States
Smillow Cancer Hosp
🇺🇸New Haven, Connecticut, United States
Regions Hospital
🇺🇸Saint Louis Park, Minnesota, United States
Perlmutter Cancer Ctr NYU
🇺🇸Mineola, New York, United States
Cleavland Clin - Taussig Cancer Ctr
🇺🇸Cleveland, Ohio, United States
Cleveland Clin - Fairview Hosp
🇺🇸Cleveland, Ohio, United States
Mark H. Zangmeister Cancer Center
🇺🇸Columbus, Ohio, United States
Cleveland Clin-Hillcrest Hosp
🇺🇸Mayfield Heights, Ohio, United States
Prov Care Clinic - Westside
🇺🇸Portland, Oregon, United States
Providence Cancer Institute
🇺🇸Portland, Oregon, United States
Vanderbilt - Ingram Cancer Center
🇺🇸Nashville, Tennessee, United States
Baylor College of Medicine
🇺🇸Houston, Texas, United States
Harris Health System
🇺🇸Houston, Texas, United States
USOR - Virginia Cancer Specialists - Fairfax Office
🇺🇸Fairfax, Virginia, United States
CHUM
🇨🇦Montreal, Canada
BioClinic Thessaloniki
🇬🇷Thessaloniki, Greece
Queen Mary Hospital - Hong Kong
🇭🇰Hong Kong, Hong Kong
Dél-pesti Centrumkórház - Országos Hematológiai és Infektológiai Intézet
🇭🇺Budapest, Hungary
Országos Onkológiai Intézet
🇭🇺Budapest, Hungary
Bács-Kiskun Megyei Oktatókórház - Kecskemét
🇭🇺Kecskemet, Hungary
Hadassah University Hospital Ein Kerem
🇮🇱Jerusalem, Israel
Shaare Zedek Medical Center
🇮🇱Jerusalem, Israel
Tokyo Metro Ctr
🇯🇵Bunkyō-Ku, Japan
Nat Cancer Ctr-Kashiwa Campus
🇯🇵Kashiwa-shi, Japan
St. Marianna Uni Hosp
🇯🇵Kawasaki, Japan
Cancer Inst Hosp of JFCR
🇯🇵Koto, Japan
Osaka Prefectural Hosp Org
🇯🇵Osaka, Japan
Gunma Prefectural Cancer Ctr
🇯🇵Ota-shi, Japan
Teine Keijinkai Hospital
🇯🇵Sapporo, Japan
National Cancer Ctr Hosp
🇯🇵Tokyo, Japan
Kyungpook Nat Uni Chilgok
🇰🇷Daegu, Korea, Republic of
Seoul Nat Uni Hospital
🇰🇷Seoul, Korea, Republic of
Hospital Nacional Daniel Alcides Carrión
🇵🇪Bellavista, Peru
SANNA - Clínica El Golf
🇵🇪San Isidro, Peru
Manila Doctors Hospital
🇵🇭Manila, Philippines
Samodzielny Publiczny Szpital Kliniczny nr 1 w Lublinie
🇵🇱Lublin, Poland
Szpital Miejski w Tychach
🇵🇱Tychy, Poland
Institute of Oncology and Radiology of Serbia (Institut za onkologiju i radiologiju Srbije)
🇷🇸Belgrade, Serbia
Trakya Universitesi Tip Fakultesi
🇹🇷Edirne, Turkey
T.C. Saglik Bakanligi - Istanbul Il Saglik Mudurlugu - Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi
🇹🇷Istanbul, Turkey
Genesis Cancer Center and Blood Institute - Hot Springs
🇺🇸Hot Springs, Arkansas, United States
Kaiser Permanente - Los Angeles Medical Center
🇺🇸Los Angeles, California, United States
Norris Comprehensive Cancer Center
🇺🇸Los Angeles, California, United States
University of California Irvine Health Chao Family Comprehensive Cancer Center
🇺🇸Orange, California, United States
UCLA Health - Santa Monica Cancer Care
🇺🇸Santa Monica, California, United States
Yale Cancer Center
🇺🇸New Haven, Connecticut, United States
Georgetown Lombardi Comprehensive Cancer Center
🇺🇸Washington, District of Columbia, United States
SCRI - Florida Cancer Specialists - South Region Research Office
🇺🇸Fort Myers, Florida, United States
SCRI - Florida Cancer Specialists - North Region Research Office
🇺🇸Saint Petersburg, Florida, United States
SCRI - Florida Cancer Specialists - Panhandle Research Office
🇺🇸Tallahassee, Florida, United States
SCRI - Florida Cancer Specialists - East Region Research Office
🇺🇸West Palm Beach, Florida, United States
University of Louisville James Graham Brown Cancer Center
🇺🇸Louisville, Kentucky, United States
Norton Cancer Institute - Poplar Level Road
🇺🇸Louisville, Kentucky, United States
Ochsner Cancer Institute
🇺🇸New Orleans, Louisiana, United States
Massachusetts General Hospital
🇺🇸Boston, Massachusetts, United States
University of Michigan Rogel Cancer Center
🇺🇸Ann Arbor, Michigan, United States
HealthPartners Cancer Center at Regions Hospital
🇺🇸Saint Louis Park, Minnesota, United States
Perlmutter Cancer Center - 38th Street
🇺🇸New York, New York, United States
Memorial Sloan Kettering Cancer Center - New York
🇺🇸New York, New York, United States
Duke University Medical Center
🇺🇸Durham, North Carolina, United States
University Hospitals Cleveland Medical Center
🇺🇸Cleveland, Ohio, United States
Providence Cancer Center Oncology and Hematology Care Westside Portland
🇺🇸Portland, Oregon, United States
Prisma Health Cancer Institute - Faris Road
🇺🇸Greenville, South Carolina, United States
Tennessee Oncology - Chattanooga - Memorial Plaza
🇺🇸Nashville, Tennessee, United States
Tennessee Oncology - Nashville - Centennial
🇺🇸Nashville, Tennessee, United States
University of Texas Southwestern Medical Center
🇺🇸Dallas, Texas, United States
The Center for Cancer & Blood Disorders - Fort Worth
🇺🇸Fort Worth, Texas, United States
Fred Hutchinson Cancer Center - Seattle Cancer Care Alliance (SCCA) Location
🇺🇸Seattle, Washington, United States
Froedtert Clinical Cancer Center
🇺🇸Milwaukee, Wisconsin, United States
Hospital Británico de Buenos Aires
🇦🇷Buenos Aires, Argentina
Instituto de Investigaciones Clínicas Mar del Plata
🇦🇷Mar del Plata, Argentina
Monash University
🇦🇺Clayton, Australia
Gosford Hospital
🇦🇺Gosford, Australia
Liverpool Hospital
🇦🇺Liverpool, Australia
Oncology West - Murdoch
🇦🇺Murdoch, Australia
Fundação Pio XII - Hospital de Câncer de Barretos - Hospital de Amor
🇧🇷Barretos, Brazil
ONCOSITE - Centro de Pesquisa Clinica Em Oncologia Ltda.
🇧🇷Ijuí, Brazil
Liga Contra o Câncer - Centro Avançado de Oncologia
🇧🇷Natal, Brazil
Hospital Ernesto Dornelles
🇧🇷Porto Alegre, Brazil
Instituto Nacional de Câncer - Brazil
🇧🇷Rio de Janeiro, Brazil
Queen Elizabeth II Health Sciences Centre-Victoria General
🇨🇦Halifax, Canada
Hôpital Notre-Dame
🇨🇦Montreal, Canada
Ottawa Hospital - General Campus
🇨🇦Ottawa, Canada
Princess Margaret Cancer Centre
🇨🇦Toronto, Canada
Sunnybrook Health Sciences Centre - Bayview Campus
🇨🇦Toronto, Canada
Icegclinic
🇨🇱La Florida, Chile
Oncovida - Santiago
🇨🇱Providencia, Chile
Hospital Puerto Montt
🇨🇱Puerto Montt, Chile
Bradford Hill Centro de Investigaciones Clinicas
🇨🇱Recoleta, Chile
Centro de Estudios Clínicos SAGA
🇨🇱Santiago, Chile
Pontificia Universidad Catolica de Chile - Escuela De Medicina - Clinica UC San Carlos de Apoq
🇨🇱Santiago, Chile
Clínica Universidad Católica del Maule - Talca
🇨🇱Talca, Chile
Institut Bergonié
🇫🇷Bordeaux cedex, France
Hôpital Morvan
🇫🇷Brest, France
Centre de Lutte contre le Cancer - François Baclesse
🇫🇷Caen Cedex 5, France
Hôpital Claude Huriez
🇫🇷Lille Cedex, France
Centre Léon Bérard
🇫🇷Lyon, France
Hôpital de la Timone
🇫🇷Marseille, France
Institut Régional du Cancer de Montpellier
🇫🇷Montpellier, France
Centre Armoricain de Radiothérapie, d'Imagerie Médicale et d'Oncologie
🇫🇷Plerin, France
Centre Hospitalier Universitaire de Poitiers
🇫🇷Poitiers, France
Institut Gustave Roussy
🇫🇷Villejuif, France
Evex Hospitals - Kutaisi Referral Hospital
🇬🇪Kutaisi, Georgia
LLC Todua Clinic
🇬🇪Tbilisi, Georgia
Ltd Tbilisi State Medical University and Ingorokva High Medical Technology University Clinic
🇬🇪Tbilisi, Georgia
New Vision University Hospital
🇬🇪Tbilisi, Georgia
Multi-profile Clinic "New Hospitals"
🇬🇪Tbilisi, Georgia
Evgenidion Clinic SA - Agia Trias
🇬🇷Athens, Greece
General Oncology Hospital of Kifisias "Agioi Anargyroi"
🇬🇷Nea Kifisia, Greece
Metropolitan Hospital
🇬🇷Neo Faliro, Greece
Medi-k Cayalá
🇬🇹Guatemala city, Guatemala
Clínica Privada Dr. Rixci Ramírez
🇬🇹Guatemala, Guatemala
Grupo Medico Angeles
🇬🇹Guatemala, Guatemala
INTEGRA Cancer Institute
🇬🇹Guatemala, Guatemala
Centro Regional de Sub Especialidades Médicas (CRESEM) SA
🇬🇹Quetzaltenango, Guatemala
Hong Kong Sanatorium and Hospital
🇭🇰Happy Valley, Hong Kong
Humanity & Health Clinical Trial Centre
🇭🇰Hong Kong, Hong Kong
Tuen Mun Hospital
🇭🇰Tuen Mun, Hong Kong
Pécsi Tudományegyetem Klinikai Központ
🇭🇺Pecs, Hungary
Davidoff Cancer Center
🇮🇱Petah Tikva, Israel
Tel Aviv Sourasky Medical Center
🇮🇱Tel Aviv, Israel
Azienda Ospedaliero - Universitaria Careggi
🇮🇹Firenze, Italy
Istituto Europeo di Oncologia
🇮🇹Milano, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Ospedale San Raffaele
🇮🇹Milan, Italy
Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) - Istituto Clinico Humanitas
🇮🇹Rozzano, Italy
Azienda Sanitaria Universitaria Friuli Centrale ? P.O. Santa Maria della Misericordia
🇮🇹Udine, Italy
Hyogo Cancer Center
🇯🇵Akashi City, Japan
University of Tokyo Hospital
🇯🇵Bunkyo-ku, Japan
Chiba Cancer Center
🇯🇵Chiba, Japan
Kyushu Cancer Center
🇯🇵Fukuoka-shi, Japan
Saitama Cancer Center
🇯🇵Ina, Japan
Kumamoto University Hospital
🇯🇵Kumamoto, Japan
Shikoku Cancer Center
🇯🇵Matsuyama-Shi, Japan
Shizuoka Cancer Center
🇯🇵Matsuyama-Shi, Japan
Aichi Cancer Center
🇯🇵Nagoya, Japan
Niigata Cancer Center Hospital
🇯🇵Niigata, Japan
Kindai University Hospital
🇯🇵Osakasayama-shi, Japan
Kanagawa Cancer Center
🇯🇵Yokohama-Shi, Japan
Dong-A University Hospital
🇰🇷Busan, Korea, Republic of
Cha Bundang Medical Center
🇰🇷Seongnam, Korea, Republic of
Asan Medical Center
🇰🇷Seoul, Korea, Republic of
Korea University Guro Hospital
🇰🇷Seoul, Korea, Republic of
Samsung Medical Center
🇰🇷Seoul, Korea, Republic of
Severance Hospital
🇰🇷Seoul, Korea, Republic of
Kauno Klinikos
🇱🇹Kaunas, Lithuania
Vilniaus Universiteto Ligoninė Santariškių Klinikos
🇱🇹Vilnius, Lithuania
Klaipedos Universitetine Ligonine
🇱🇹Klaipeda, Lithuania
Nacionalinis Vėžio Institutas
🇱🇹Vilnius, Lithuania
Hospital Pulau Pinang
🇲🇾George Town, Malaysia
Hospital Kuala Lumpur
🇲🇾Kuala Lumpur, Malaysia
Pusat Perubatan Universiti Malaya
🇲🇾Kuala Lumpur, Malaysia
Hospital Umum Sarawak
🇲🇾Kuching, Malaysia
CLIMERS Clinical Medical Research
🇲🇽Colonia Centro, Mexico
Centro de Atención e Investigación Clínica en Oncología
🇲🇽Merida, Mexico
Centro Especializado en Investigacion y Tratamiento Oncologicos SC
🇲🇽Mexico DF, Mexico
Hospital Zambrano Hellion TecSalud
🇲🇽San Pedro Garza García, Mexico
Centro Hemato - Oncológico Privado (CHOP)
🇲🇽Toluca de Lerdo, Mexico
Hospital Maria Auxiliadora
🇵🇪San Juan De Miraflores, Peru
Instituto Nacional de Enfermedades Neoplásicas
🇵🇪Surquillo, Peru
Dr Pablo O. Torre Memorial Hospital - Riverside Medical Center
🇵🇭Bacolod City, Philippines
Baguio General Hospital and Medical Center
🇵🇭Baguio, Philippines
Cebu Doctors' University Hospital
🇵🇭Cebu City, Philippines
Centrum Onkologii Ziemi Lubelskiej im. św. Jana z Dukli
🇵🇱Lublin, Poland
Narodowy Instytut Onkologii im. Marii Skłodowskiej-Curie - Państwowy Instytut Badawczy
🇵🇱Warszawa, Poland
Centro Hospitalar e Universitário de Coimbra
🇵🇹Coimbra, Portugal
Fundação D. Anna de Sommer Champalimaud e Dr. Carlos Montez Champalimaud
🇵🇹Lisboa, Portugal
Instituto Português de Oncologia do Porto Francisco Gentil
🇵🇹Porto, Portugal
Spitalul Judetean de Urgenta
🇷🇴Baia Mare, Romania
Institutul Clinic Fundeni
🇷🇴Bucharest, Romania
Institutul Oncologic Prof. Dr. Ion Chiricuta
🇷🇴Cluj-Napoca, Romania
Medisprof
🇷🇴Cluj-Napoca, Romania
Centrul De Oncologie Sf Nectarie
🇷🇴Craiova, Romania
Centrul de Radioterapie Amethyst Cluj
🇷🇴Florești, Romania
Centrul de Oncologie Euroclinic
🇷🇴Iasi, Romania
Clinica SIGMedical
🇷🇴Suceava, Romania
University Hospital Medical Center (KBC) Bezanijska Kosa
🇷🇸Belgrade, Serbia
Clinical Center Kragujevac
🇷🇸Kragujevac, Serbia
Hospital Universitari Vall d'Hebrón
🇪🇸Barcelona, Spain
Institut Català d'Oncologia - Hospital Duran i Reynals (ICO L'Hospitalet)
🇪🇸Barcelona, Spain
Hospital General Universitario Gregorio Marañón
🇪🇸Madrid, Spain
Hospital Universitario HM Sanchinarro
🇪🇸Madrid, Spain
Hospital Universitario Ramón y Cajal
🇪🇸Madrid, Spain
Hospital Universitario Marqués de Valdecilla
🇪🇸Santander, Spain
Hospital Clínico Universitario de Valencia
🇪🇸Valencia, Spain
Hospital Universitario Miguel Servet
🇪🇸Zaragoza, Spain
Faculty of Medicine Siriraj Hospital
🇹🇭Bang Phlat, Thailand
Songklanagarind Hospital
🇹🇭Hat Yai, Thailand
Sunpasitthiprasong Hospital
🇹🇭Ubon Ratchathani, Thailand
T.C. Saglik Bakanligi Adana Sehir Egitim ve Arastirma Hastanesi
🇹🇷Adana, Turkey
Memorial Ankara Hastanesi
🇹🇷Ankara, Turkey
Kocaeli Üniversitesi Araştırma ve Uygulama Hastanesi
🇹🇷Izmit, Turkey
Inönü Üniversitesi Turgut Özal Tıp Merkezi
🇹🇷Malatya, Turkey
Ankara Üniversitesi Tıp Fakültesi - Cebeci Araştırma ve Uygulama Hastanesi
🇹🇷Mamak, Turkey
Van Yüzüncü Yıl Üniversitesi Dursun Odabaş Tıp Merkezi
🇹🇷Van, Turkey
Ataturk Universitesi Arastirma Hastanesi
🇹🇷Yakutiye, Turkey
Başkent Üniversitesi Adana Dr Turgut Noyan Uygulama ve Araştirma Merkezi
🇹🇷Yüreğir, Turkey
Barts Health NHS Trust
🇬🇧London, United Kingdom
Sarah Cannon Research Institute London
🇬🇧London, United Kingdom
The Royal Marsden NHS Foundation Trust
🇬🇧Sutton, United Kingdom
University College London Hospitals NHS Foundation Trust
🇬🇧London, United Kingdom
The Christie NHS Foundation Trust
🇬🇧Manchester, United Kingdom
Oxford University Hospitals NHS Foundation Trust
🇬🇧Oxford, United Kingdom