Early prediction of treatment response in children with Inflammatory Bowel Disease with Intestinal Ultrasound

Recruiting

• Conditions: chronic inflammation of the bowel; Inflammatory Bowel Disease; 10017969

• Registration Number: NL-OMON51551
• Lead Sponsor: Academisch Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 9 April 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 120

Inclusion Criteria

Age 3-18y
Newly onset IBD or flare IBD
Starting new remission induction therapy

Exclusion Criteria

No visible abnormalities on baseline IUS
Infectious gastroenteritis
Acute severe ulcerative colitis
Surgery as remission induction therapy
Previous intestinal surgery
Pregnancy

Study & Design

• Study Type: Observational non invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>To assess the early predictive value of IUS at week 6 for therapy response<br /><br>after 3 months in children with newly onset IBD starting therapy and children<br /><br>with known IBD starting on remission induction therapy. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>1. Predictive value of IUS at week 2 for treatment response at week 13.<br /><br>2. To assess the difference in change of IUS parameters between different types<br /><br>of remission induction therapy and types of IBD (CD versus UC).<br /><br>3. Predictive value of transmural healing at week 13 as assessed by IUS for<br /><br>remission at week 52. </p><br>