Prediction of medication response in children with Attention Deficit Hyperactivity Disorder (ADHD): Electroencephalogram (EEG) differences between responders and non-responders to methylphenidate

Not Applicable

Completed

• Conditions: Medication response in children with Attention Deficit Hyperactivity Disorder (ADHD); Mental and Behavioural Disorders; Hyperkinetic disorders

• Registration Number: ISRCTN32841168
• Lead Sponsor: trecht Institute for Pharmaceutical Sciences (The Netherlands)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2007-07-16
• Study Completion: 2007-08-31
• Last Update Posted: 8 November 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

1. Diagnosed with ADHD combined type (no primary diagnoses of attention deficit) according to Diagnostic and Statistic Manual of mental disorders - fourth edition - criteria (DSM IV, APA 1994)
2. They have (no history of) anxiety disorder, depression, tics, psychosis or autism
3. Their age is ranged between 7 and 12
4. Intelligence Quotient (IQ) is above 75
5. They are free from psychoactive medication
6. They are free from methylphenidate at least 48 hours before testing
7. They have no known cardiovascular disease
8. Normal static binocular acuity, corrected or uncorrected
9. Written informed consent from the parents

Exclusion Criteria

1. IQ is below 75
2. One or more of the following co-morbid disorders are diagnosed:
2.1. Anxiety disorder
2.2. Depression
2.3. Tics
2.4. Psychosis
2.5. Autism
3. Prior enrolment in the same study
4. Participation in another clinical trial simultaneously
5. Familiar with epileptic disorders
6. Long term usage of methylphenidate (greater than three months)

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Primary outcome measure is the absolute and relative power in different frequency bands of the EEG.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Event-related potentials in response to the stop-task and Continuous Performance Test (CPT)<br> 2. EEG coherence<br> 3. Scores on the Spatial Span (SSP) task and Spatial Working Memory (SWM) task from the Cambridge Neuropsychological Test Automated Battery (CANTAB)<br> 4. Gene polymorphisms of the dopamine D4 receptor (DRD4), dopamine transporter (DAT1), and serotonin transporter (5-HTT)<br> 5. Scores on the 18-item Swanson, Nolan and Pelham Teacher and Parent Rating Scale (SNAP-IV)<br>