Biomarkers Estimation in Stroke
Not Applicable
- Conditions
- Health Condition 1: null- Having neurological symptoms at hospital admission suspicious for acute stroke
- Registration Number
- CTRI/2018/07/015026
- Lead Sponsor
- Christian Medical College
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Presence of neurological symptoms at hospital admission suspicious for acute stroke
2. Time interval from symptom onset to study inclusion < 12 h
Exclusion Criteria
1. Ischemic stroke, intracerebral hemorrhage or transient ischemic attack within the last three months
2. Patients participating in other stroke trials/research
3. Known history of brain tumor at any time in patient history
4. Evidence for traumatic brain injury with the last 3 months
5. Participant in another stroke study
6. Informed consent not given
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Diagnostic accuracy (sensitivity, specificity, positive predictive value, negative predictive value) of GFAP for differentiating patients with ICH from patients with ischemic stroke (including TIA) and stroke mimics. <br/ ><br> <br/ ><br>2. Gold standard is the diagnosis of ICH, ischemic stroke (including TIA), or stroke mimic as determined at the end of hospital stay based on all available information. <br/ ><br>Timepoint: 1 month after the end of recruitment phase
- Secondary Outcome Measures
Name Time Method 1. Analysis stratified for patients with a moderate to severe neurological deficit (NIHSS 9). <br/ ><br> <br/ ><br>2. Analysis stratified for patients with different time windows (2 h, 2 to 6 h, 6 to 12 h) from symptom onset to blood withdrawal. <br/ ><br> <br/ ><br>3. Correlation between GFAP values and ICH volume and location. <br/ ><br>Timepoint: At the time of result analysis